Results 51 to 60 of about 198,497 (264)
Advanced Science, EarlyView.Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He +6 more
wiley +1 more source
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
Advanced Science, EarlyView.This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan +12 more
wiley +1 more source
Extraction and purification of antioxidative flavonoids from Chionanthus retusa leaf
Frontiers in Bioengineering and Biotechnology, 2022 In this work, flavonoids from the leaves of Chionanthus retusa were extracted using alcohol, and the extraction yield was optimized by single-factor and orthogonal experiments.
Zhen Wang +3 more
doaj +1 more source
High-Throughput Virtual Screening of 4487 flavonoids: New insights on the structural inhibition of SARS-CoV-2 Main Protease [PDF]
arXiv, 2020 COVID-19 presents a great threat to public health worldwide and the infectious agent SARS-CoV-2 is currently the target of much research aiming at inhibition. The virus' main protease is a dimeric enzyme that has only recently begun to be thoroughly described, opening the door for virtual screening more broadly. Here, a PAIN-filtered flavonoid database
arxiv
Direct Quantification of Protein–Protein Interactions in Living Bacterial Cells
Advanced Science, EarlyView.Quantitative measurement of protein–protein interactions in living cells is vital for biotechnology applications. Fluorescence resonance energy transfer (FRET) signals in bacterial cells are often weak, leading to false‐positive. Quantitative FRET measurements are implemented to overcome the weak FRET signal.
Soojung Yi +12 more
wiley +1 more source
Advanced Science, EarlyView.Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang +10 more
wiley +1 more source
Chemistry and Biological Activities of Flavonoids: An Overview
The Scientific World Journal, 2013 There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health,
Shashank Kumar, Abhay K. Pandey
doaj +1 more source
Purification of total flavonoids from Aurea Helianthus flowers and In Vitro Hypolipidemic Effect [PDF]
arXiv, 2019 The effects of purification methods and its hypolipidemic function on the total flavonoids of Aurea Helianthus flower were investigated. Liquid-liquid extraction of ethanol extract from Aurea Helianthus flower was carried out by using different polar solvents. The extract with the highest total flavonoid content was selected, and the optimal conditions
arxiv
A Solution‐Based Deposition Method Enabling Pigment Blue Edible Electrochemical Transistors
Advanced Science, EarlyView.A novel solution‐based method is presented to produce Copper Phthalocyanine fibrous films displaying effective ion permeability and enhanced transconductance in electrolyte‐gated transistors architectures. Using these films, the first instance of a fully edible electrolyte‐gated transistor with volumetric capacitance, targeting in‐body applications, is
Alessandro Luzio +10 more
wiley +1 more source