Results 91 to 100 of about 27,453 (182)

Differentially expressed proteins in fluconazole-susceptible and fluconazole-resistant isolates of Candida glabrata.

Drug discoveries & therapeutics, 2015
The current study aimed to identify the differences presented in the proteome of fluconazole-susceptible isolates of Candida glabrata compared to those with fluconazole-resistant ones. Two-dimensional differential gel electrophoresis was applied to identify proteins that were differentially expressed in fluconazole-susceptible and fluconazole-resistant
Shen, Yinzhong, Zhang, Lijun, Jia, Xiaofang, Zhang, Yongxin, Lu, Hongzhou   +4 more
openaire   +2 more sources

Incidence of fluconazole resistance in candida spp. among immunocompromised patients [PDF]

, 2023
Objective: To determine fluconazole resistance in Candida spp. Among immunocompromised patients. Methodology: This study included of total 100 Bronchoalveolar lavage fluid samples of cancer patients, which comprised 37 lung cancer, 19 lymphoma, 18 ...
Basit Zeshan, Madiha Asghar
core  

First multicentre report of in vitro resistance rates in candidaemia isolates in Turkey

, 2019
Objectives: This study investigated the antifungal resistance rates of isolates from candidaemia patients in 12 tertiary-care centres in Turkey. Methods: A total of 1991 Candida spp.

core   +1 more source

Mechanisms of fluconazole resistance in Candida parapsilosis clinical isolates

, 2013
Candida parapsilosis is an emerging fungal pathogen and a leading cause of hospital-acquired bloodstream fungal infections. The prophylactic and long-term use of fluconazole, a widely used antifungal, has resulted in an increased prevalence of resistance
Wanamaker, Eileen B.
core  

Fluconazole-resistant oral candidosis in a repeatedly treated female AIDS patient. [PDF]

, 1994
Bogner, Johannes R., Eva Thoma‐Greber, H. C. Korting, Goebel, Frank-Detlef, Korting, H. C., Thoma-Greber, E., F.‐D. Goebel, J. Bogner   +7 more
core   +1 more source

Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts.

PLoS Genetics
Antifungal drug resistance is a major challenge in fungal infection management. Numerous genomic changes are known to contribute to acquired drug resistance in clinical isolates of specific pathogens, but whether they broadly explain natural resistance ...
Marie-Claire Harrison, David C Rinker, Abigail L LaBella, Dana A Opulente, John F Wolters, Xiaofan Zhou, Xing-Xing Shen, Marizeth Groenewald, Chris Todd Hittinger, Antonis Rokas   +9 more
doaj   +1 more source

Fluconazole-Resistant Vulvovaginal Candidosis: An Update on Current Management

Pharmaceutics
Currently, the rising prevalence of resistant Candida species, particularly Candida albicans, as well as non-albicans isolates such as Candida glabrata and Candida krusei, represent challenges in their management. In this review, we aimed to explore the current management of fluconazole-resistant vulvovaginal candidiasis (FRVVC).
Karolina Akinosoglou, Achilleas Livieratos, Konstantinos Asimos, Francesca Donders, Gilbert G. G. Donders   +4 more
openaire   +4 more sources

Risk factors and outcome for bloodstream infections due to fluconazole-resistant candida parapsilosis: A 22-year single-center retrospective study

Candidemia ranks among the top causes of nosocomial bloodstream infections, significantly increasing hospital stays and costs. Rapid and effective empirical antifungal therapy is crucial.
Agca, Harun, Heper, Yasemin, Akalin, Halis, Ener, Beyza, Kazak, Esra, Ak, Secil, Ozkaya, Guven, Semet, Cihan, Yilmaz, Emel   +8 more
core   +1 more source

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

, 2012
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole.
Dandapani, Sivaraman, Bittker, Joshua A., Palmer, Michelle, Lindquist, Susan, Dockendorff, Chris, Hartland, Cathy L., Schreiber, Stuart L., Youngsaye, Willmen, Whitesell, Luke, Munoz, Benito   +9 more
core   +1 more source

Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp.

, 2016
Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated ...
Jessica A. DiGirolamo (2352094), Alice M. Clark (1523287), Daneel Ferreira (1320120), Melissa R. Jacob (1315035), Xing-Cong Li (682615)   +4 more
core   +1 more source