Results 111 to 120 of about 27,610 (210)

Risk factors and outcome for bloodstream infections due to fluconazole-resistant candida parapsilosis: A 22-year single-center retrospective study [PDF]

Candidemia ranks among the top causes of nosocomial bloodstream infections, significantly increasing hospital stays and costs. Rapid and effective empirical antifungal therapy is crucial.
Agca, Harun, Heper, Yasemin, Akalin, Halis, Ener, Beyza, Kazak, Esra, Ak, Secil, Ozkaya, Guven, Semet, Cihan, Yilmaz, Emel   +8 more
core   +2 more sources

Fluconazole and Ibuprofen Combination: A Potential Treatment for Mucosal Candidiasis

Medical Laboratory Journal, 2020
Background and objectives: The incidence of drug-resistant candidiasis has increased dramatically. This study aimed to evaluate antifungal effects of fluconazole alone and in combination with ibuprofen on isolates from patients with mucosal candidiasis.  
Tahere Shamoushaki, Leila Fozouni
doaj  

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Epidemiology of oral candidiasis in HIV-infected patients: Colonization, infection, treatment, and emergence of fluconazole resistance [PDF]

, 1994
: To study the epidemiology of oral candidiasis and the effect of treatment of thrush in human immunodeficiency virus (HIV)-infected patients.: We conducted a prospective observational study of 92 patients over 1 year, including a nonblinded, randomized ...
Bradley, Suzanne F., Zarins, Lidija T., He, Xiaogang, Kauffman, Carol A., Sangeorzan, Jon A., Ridenour, George L., Tiballi, Robert N.   +6 more
core   +1 more source

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

mSphere, 2017
Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans.
Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos   +14 more
doaj   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles [PDF]

, 2012
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole.
Dandapani, Sivaraman, Bittker, Joshua A., Palmer, Michelle, Lindquist, Susan, Dockendorff, Chris, Hartland, Cathy L., Schreiber, Stuart L., Youngsaye, Willmen, Whitesell, Luke, Munoz, Benito   +9 more
core   +1 more source

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates

mBio
Fluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 ...
Brooke D. Esquivel, Amanda Santos, Jeffrey M. Rybak, Darian J. Santana, P. David Rogers, Theodore C. White   +5 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp. [PDF]

, 2016
Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated ...
Jessica A. DiGirolamo (2352094), Alice M. Clark (1523287), Daneel Ferreira (1320120), Melissa R. Jacob (1315035), Xing-Cong Li (682615)   +4 more
core   +1 more source