Results 121 to 130 of about 2,379,902 (206)

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp.

, 2016
Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated ...
Jessica A. DiGirolamo (2352094), Alice M. Clark (1523287), Daneel Ferreira (1320120), Melissa R. Jacob (1315035), Xing-Cong Li (682615)   +4 more
core   +1 more source

First Case of Candidemia With Fluconazole-Resistant Candida albicans and Y132H Mutations in ERG11 Gene From Pakistan

Case Reports in Infectious Diseases
Candida albicans is one of the critical priority fungal pathogens as classified by the World Health Organization. Fluconazole resistance in C. albicans is increasingly being reported from different parts of the world.
Nosheen Nasir, Joveria Farooqi, Iffat Khanum, Sadaf Zaka, Shariqa Batool, Najia Ghanchi, Kauser Jabeen   +6 more
doaj   +1 more source

Fluconazole-Resistant Vulvovaginal Candidosis: An Update on Current Management

Pharmaceutics
Currently, the rising prevalence of resistant Candida species, particularly Candida albicans, as well as non-albicans isolates such as Candida glabrata and Candida krusei, represent challenges in their management. In this review, we aimed to explore the current management of fluconazole-resistant vulvovaginal candidiasis (FRVVC).
Karolina Akinosoglou, Achilleas Livieratos, Konstantinos Asimos, Francesca Donders, Gilbert G. G. Donders   +4 more
openaire   +4 more sources

Susceptibilities of Candida species to amphotericin B and fluconazole: The emergence of fluconazole resistance in Candida tropicalis

, 2008
[[abstract]]OBJECTIVE: To determine the susceptibilities of Candida species isolated from Taiwan to amphotericin B and fluconazole. DESIGN: Prospective surveillance study. METHODS: Each hospital was asked to submit up to 10 C.
Yang, YL; Ho, YA; Cheng, HH; Ho, M; Lo, HJ
core   +1 more source

Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts.

PLoS Genetics
Antifungal drug resistance is a major challenge in fungal infection management. Numerous genomic changes are known to contribute to acquired drug resistance in clinical isolates of specific pathogens, but whether they broadly explain natural resistance ...
Marie-Claire Harrison, David C Rinker, Abigail L LaBella, Dana A Opulente, John F Wolters, Xiaofan Zhou, Xing-Xing Shen, Marizeth Groenewald, Chris Todd Hittinger, Antonis Rokas   +9 more
doaj   +1 more source

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

, 2012
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole.
Dandapani, Sivaraman, Bittker, Joshua A., Palmer, Michelle, Lindquist, Susan, Dockendorff, Chris, Hartland, Cathy L., Schreiber, Stuart L., Youngsaye, Willmen, Whitesell, Luke, Munoz, Benito   +9 more
core   +1 more source

Characteristics of Candida isolates from patients with diabetes mellitus. [PDF]

, 2006
The present research has investigated the molecular characterization of oral yeasts in healthy individuals from different dental clinical settings in the United Kingdom, and patients from the UK and Italy who were affected by diabetes mellitus (DM) to ...
Manfredi, M.
core  

Polymorphic genes in Esc strains show overlap with genes associated with fluconazole resistance.

Polymorphic genes in Esc strains show overlap with genes associated with fluconazole resistance.
Andrew W. Day (17996408), Carol A. Kumamoto (8098571)   +1 more
core   +1 more source