Results 121 to 130 of about 27,610 (210)

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Fluconazole resistance Candida albicans in females with recurrent vaginitis and Pir1 overexpression [PDF]

, 2015
Background: Some genes may be associated with Candida albicans resistance to azoles. Pir1 gene is described as responsible to induce resistance in C. albicans.
Roudbari, M., Nikoomanesh, F., Nasrollahi, Z., Poor, M.H., Bazl, M.R., Yadegari, M.H., Mohammadi, S.R.   +6 more
core  

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea [PDF]

, 2009
The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development.
Pradier Jean-Marc, Pradier, J.M., Walker, Anne-Sophie, Mernke, Dennis, Pradier, Jean Marc, J. M., Leroux, Pierre, Matthias Hahn, Matthias Kretschmer, Sabine Fillinger, Walker, Anne Sophie, Kretschmer, M., Hahn, Matthias, Fillinger Sabine, Jean-Marc Pradier, Mosbach, Andreas, Walker, A.S., Mernke, Denis, Kretschmer Matthias, Mernke, D., Fillinger, S., de Waard, Maarten A, Maarten A De Waard, Walker, Anne Sophie, A. S., Leroux, P., de Waard, M.A., De Waard Maarten A., Leroux Pierre, Fillinger-David, Sabine, Helma, S. H., Anne-Sophie Walker, Pierre Leroux, Waard, Maarten A. De, Schoonbeek, Henk-jan, Leroch, Michaela, Leroch, M., Pradier, Jean Marc, Leroux, Pierre, P., Mosbach, A., Waard, M.A., de, Dennis Mernke, Pradier, Jean-Marc, Hahn Matthias, Leroch Michaela, Walker Anne-Sophie, Schoonbeek Henk-Jan, Fillinger-David, Sabine, Helma, Henk-Jan Schoonbeek, Mernke Dennis, Fillinger, Sabine, Mosbach Andreas, Andreas Mosbach, Michaela Leroch, Kretschmer, Matthias, Schoonbeek, H.J., Hahn, M.   +53 more
core   +1 more source

Multidrug-resistant Candida glabrata strains obtained by induction of anidulafungin resistance in planktonic and biofilm cells

Brazilian Journal of Pharmaceutical Sciences, 2019
Candida glabrata has emerged as a common cause of serious life-threatening fungal infections, largely owing to their low susceptibility to azole antifungals. Recent guidance indicates the use of echinocandins as the first-choice drug for the treatment of
Camila Hatwig, Eduardo A. Balbueno, Vanessa Z. Bergamo, Bruna Pippi, Alexandre M. Fuentefria, Gustavo P. Silveira   +5 more
doaj   +1 more source

Differentially expressed proteins in fluconazole-susceptible and fluconazole-resistant isolates of Candida glabrata.

Drug discoveries & therapeutics, 2015
The current study aimed to identify the differences presented in the proteome of fluconazole-susceptible isolates of Candida glabrata compared to those with fluconazole-resistant ones. Two-dimensional differential gel electrophoresis was applied to identify proteins that were differentially expressed in fluconazole-susceptible and fluconazole-resistant
Shen, Yinzhong, Zhang, Lijun, Jia, Xiaofang, Zhang, Yongxin, Lu, Hongzhou   +4 more
openaire   +2 more sources

Incidence of fluconazole resistance in candida spp. among immunocompromised patients [PDF]

, 2023
Objective: To determine fluconazole resistance in Candida spp. Among immunocompromised patients. Methodology: This study included of total 100 Bronchoalveolar lavage fluid samples of cancer patients, which comprised 37 lung cancer, 19 lymphoma, 18 ...
Basit Zeshan, Madiha Asghar
core  

Fluconazole-resistant oral candidosis in a repeatedly treated female AIDS patient. [PDF]

, 1994
Bogner, Johannes R., Eva Thoma‐Greber, H. C. Korting, Goebel, Frank-Detlef, Korting, H. C., Thoma-Greber, E., F.‐D. Goebel, J. Bogner   +7 more
core   +1 more source

Identification and expression of multidrug transporters responsible for fluconazole resistance in Candida dubliniensis [PDF]

, 1998
Candida dubliniensis is a recently described Candida species associated with oral candidosis in human immunodeficiency virus (HIV)-infected and AIDS patients, from whom fluconazole-resistant clinical isolates have been previously recovered.
Coleman, D. C., Donnelly, S. M., Sanglard, D., Shanley, D. B., Sullivan, D. J., Moran, G. P.   +5 more
core  

Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts.

PLoS Genetics
Antifungal drug resistance is a major challenge in fungal infection management. Numerous genomic changes are known to contribute to acquired drug resistance in clinical isolates of specific pathogens, but whether they broadly explain natural resistance ...
Marie-Claire Harrison, David C Rinker, Abigail L LaBella, Dana A Opulente, John F Wolters, Xiaofan Zhou, Xing-Xing Shen, Marizeth Groenewald, Chris Todd Hittinger, Antonis Rokas   +9 more
doaj   +1 more source

Fluconazole-Resistant Vulvovaginal Candidosis: An Update on Current Management

Pharmaceutics
Currently, the rising prevalence of resistant Candida species, particularly Candida albicans, as well as non-albicans isolates such as Candida glabrata and Candida krusei, represent challenges in their management. In this review, we aimed to explore the current management of fluconazole-resistant vulvovaginal candidiasis (FRVVC).
Karolina Akinosoglou, Achilleas Livieratos, Konstantinos Asimos, Francesca Donders, Gilbert G. G. Donders   +4 more
openaire   +4 more sources