Results 81 to 90 of about 2,379,902 (206)

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, T. S. Harrison, J. Day, Loyse, A   +9 more
core   +1 more source

Vaginal Lactobacillus paragasseri may attenuate fluconazole-resistant phenotypes in the subset of Candida albicans isolates and shows potential as a probiotic adjunct in antifungal therapy

Frontiers in Microbiology
IntroductionCandida albicans is the predominant etiological agent of vulvovaginal candidiasis (VVC). Fluconazole (FLU), a first-line azole antifungal agent, has encountered growing resistance among vaginal isolates of C.
Qiuyue Wang, Hua Wang, Huirong Pan, Zhongyan Xu, Qi Cui, Huihai Zhao, Keran Jia, Fukun Wang   +7 more
doaj   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source

Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata

mSphere, 2018
The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis.
Sarah G. Whaley, Kelly E. Caudle, Lucia Simonicova, Qing Zhang, W. Scott Moye-Rowley, P. David Rogers   +5 more
doaj   +1 more source

Consensus recommendations for Trichophyton indotineae: A modified Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A modified Delphi consensus for suspected terbinafine‐resistant T. indotineae: confirm dermatophytes with KOH microscopy/culture and species‐level PCR/ITS sequencing. Itraconazole is recommended as first‐line systemic therapy, with luliconazole 1% cream as a topical adjunct. Posaconazole may be considered if itraconazole fails, while keeping antifungal
Aditya K. Gupta, Mesbah Talukder, Ditte Marie L. Saunte, Roderick James Hay, Michael Arabatzis, Avrom S. Caplan, Eran Galili, Eckart Haneke, Matilde Iorizzo, Riad Kassem, Ananta Khurana, Shari R. Lipner, Anna Lyakhovitsky, Brian W. Morrison, Vincent Piguet, Bianca Maria Piraccini, Carmen Rodríguez‐Cerdeira, Avner Shemer, Michela Starace, Olav Sundnes, Antonella Tosti   +20 more
wiley   +1 more source

MOLECULAR MECHANISMS OF DRUG RESISTANCE IN CANDIDA ALBICANS: ROLE OF TRANSCRIPTION FACTORS MCM1 AND ADA2 [PDF]

, 2011
Candida albicans is an opportunistic fungal pathogen responsible for localized as well as disseminated infections. C. albicans is the most commonly isolated specie from blood cultures, accounting for over 60% of all Candida isolates. The fungistatic drug
MOGAVERO, SELENE
core  

Platelet‐Rich Fibrins as Local Drug‐Delivery Carriers

Journal of Periodontal Research, EarlyView.
Autologous platelet concentrates (APCs), particularly platelet‐rich fibrin (PRF), act as biologically active fibrin scaffolds, capable of entrapping and gradually releasing therapeutic agents in oral and periodontal therapy. The incorporation of bioactive compounds, such as antibiotics, antifungals, vitamins, antidiabetic drugs, and exosomes, enhances ...
Karim M. Fawzy El‐Sayed, Christof E. Dörfer   +1 more
wiley   +1 more source

Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols

Photochemistry and Photobiology, EarlyView.
This review addresses the critical challenges in translating in vitro antimicrobial photodynamic therapy protocols to in vivo models, with a particular focus on the hurdles of standardization. The vast diversity in photosensitizers and light parameters across different target cells and models requires a rigorous optimization process.
Lívia Mara Alves Figueiredo‐Godoi, Ana Júlia Barbosa Tomé, Cristina Kurachi   +2 more
wiley   +1 more source

Lipase Gene Expression of Resistant and Sensitive Candida Albicans to Fluconazole Isolated from Patients Suffering from Oral Candidiasis and Vaginal Candidiasis

Medical Laboratory Journal, 2015
Background and Objective: With the development of drug resistance in strains of fungi, there is a considerable resistance of Candida albicans strains to fluconazole. Molecular studies are developing to determine the relationship of such a drug resistance
Nasrollahi Omran, A, Nazemi, A, Kihanian, SH, Aryana , N   +3 more
doaj