Results 11 to 20 of about 40,564 (224)

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region

open access: yesJournal of Global Antimicrobial Resistance, 2020
Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey   +3 more
doaj   +3 more sources

Molecular Evaluation of the mRNA Expression of the ERG11, ERG3, CgCDR1, and CgSNQ2 Genes Linked to Fluconazole Resistance in Candida glabrata in a Colombian Population [PDF]

open access: yesJournal of Fungi
Introduction: The study of Candida glabrata genes associated with fluconazole resistance, from a molecular perspective, increases the understanding of the phenomenon with a view to its clinical applicability.
Leidy Yurany Cárdenas Parra   +3 more
doaj   +2 more sources

Fluconazole resistance in Candida species: a current perspective

open access: yesInfection and Drug Resistance, 2017
Elizabeth L Berkow, Shawn R Lockhart Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA Abstract: Candida albicans and the emerging non-albicans Candida spp.
Berkow EL, Lockhart SR
doaj   +3 more sources

Fingolimod potentiates the antifungal activity of fluconazole against fluconazole-resistant Candida auris

open access: yesFrontiers in Cellular and Infection Microbiology
Candida auris has emerged as a critical nosocomial pathogen that particularly affects immunocompromised and critically ill patients in intensive care units, and it is associated with high mortality.
Ji-Hui Bae, Yong-Bin Eom, Yong-Bin Eom
doaj   +3 more sources

Ibuprofen-Mediated Reversal of Fluconazole Resistance in Clinical Isolates of Candida [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2015
Introduction: In view of the increasing prevalence of invasive Candidiasis in today’s health-care scenario and the emergence of fluconazole resistance among clinical isolates of Candida, we sought to determine if Ibuprofen could elicit a reversal of ...
Monika Sharma   +6 more
doaj   +1 more source

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

open access: yesMicroorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma   +12 more
doaj   +1 more source

Fluconazole resistance in Candida glabrata [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 1993
We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts.
C A, Hitchcock   +4 more
openaire   +2 more sources

Fluconazole Assists Berberine To Kill Fluconazole-Resistant Candida albicans [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 2013
ABSTRACT It was found in our previous study that berberine (BBR) and fluconazole (FLC) used concomitantly exhibited a synergism against FLC-resistant Candida albicans in vitro . The aim of the present study was to clarify how BBR and FLC worked synergistically and the underlying mechanism ...
De-Dong, Li   +10 more
openaire   +2 more sources

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

open access: yesmBio, 2020
Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak   +12 more
doaj   +1 more source

Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]

open access: yes, 2016
Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia   +7 more
core   +12 more sources

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