Results 41 to 50 of about 27,453 (182)

Whole Genome Sequencing Shows Genetic Diversity, as Well as Clonal Complex and Gene Polymorphisms Associated with Fluconazole Non-Susceptible Isolates of Candida tropicalis

Journal of Fungi, 2022
Resistance to azoles in Candida tropicalis is increasing and may be mediated by genetic characteristics. Using whole genome sequencing (WGS), we examined the genetic diversity of 82 bloodstream C.
Caitlin Keighley, Mailie Gall, Sebastiaan J. van Hal, Catriona L. Halliday, Louis Yi Ann Chai, Kean Lee Chew, Chayanika Biswas, Monica A. Slavin, Wieland Meyer, Vitali Sintchenko, Sharon C. A. Chen   +10 more
doaj   +1 more source

The Synergism of the Small Molecule ENOblock and Fluconazole Against Fluconazole-Resistant Candida albicans [PDF]

Frontiers in Microbiology, 2019
Candida albicans is the most common opportunistic fungal pathogen which can cause life-threatening bloodstream infections known as candidaemia. It is very important to discover new drugs and targets for the treatment of candidaemia. In this study, we first investigated the combination antifungal effects of the small molecule ENOblock and fluconazole ...
Liping Li, Teng Zhang, Jianrong Xu, Jing Wu, Yida Wang, Xiran Qiu, Yu Zhang, Weitong Hou, Lan Yan, Maomao An, Yuanying Jiang   +10 more
openaire   +3 more sources

Short-term evolution and dispersal patterns of fluconazole-resistance in Candida auris clade III. [PDF]

mBio
The rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is
Cancino-Muñoz I, Mulet-Bayona JV, Salvador-García C, Tormo-Palop N, Guna R, Gimeno-Cardona C, González-Candelas F.   +6 more
europepmc   +2 more sources

Synergistic Activity of Chloroquine with Fluconazole against Fluconazole-Resistant Isolates of Candida Species [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT The in vitro activity of chloroquine and the interactions of chloroquine combined with fluconazole against 37 Candida isolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests.
Yali, Li, Zhe, Wan, Wei, Liu, Ruoyu, Li
openaire   +2 more sources

Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms [PDF]

Journal of Antimicrobial Chemotherapy, 2002
Fluconazole alone does not demonstrate any contact activity against resistant organisms. Phenolic antioxidants, such as butylated hydroxyanisole, appear to promote fluconazole activity resulting in the killing of 10(4) cfu/mL of 11 resistant Candida albicans strains within 3-15 min and of 10(4) cfu/mL of 10 resistant Escherichia coli strains within 6 ...
SIMONETTI, Giovanna, VILLA, Adelaide, SIMONETTI, Nicola   +2 more
openaire   +4 more sources

Correlation between ERG11 Gene Mutations and Fluconazole Resistance in Candida albicans Strains Isolated from Rasht in Years 2015-2016 [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Candida albicans as an opportunistic fungal pathogen in human causes candidiasis. The widespread use of azoles has led to the increase of azole resistance in Candida albicans isolates.
Saeedeh Balabandi, Zeinab Khazaei-Koohpar, Najmeh Ranji   +2 more
doaj  

Fluconazole Resistance among Oral Candida Isolates from People Living with HIV/AIDS in a Nigerian Tertiary Hospital

Journal of Fungi, 2017
Oropharyngeal candidiasis, a common fungal infection in people living with HIV/AIDS (PLWHA), arises from Candida species colonizing the oral cavity. Fluconazole is the preferred treatment and is often used empirically.
Iriagbonse I. Osaigbovo, Patrick V. Lofor, Rita O. Oladele   +2 more
doaj   +1 more source

Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates

Saudi Pharmaceutical Journal, 2022
Candida species have a major role in nosocomial infections leading to high morbidity and mortality. Increased resistance to various antifungals, especially azoles is a significant problem.
Amira M. El-Ganiny, Hend A. Kamel, Nehal E. Yossef, Basem Mansour, Ahmed M. El-Baz   +4 more
doaj   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

mSphere, 2023
Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals.
Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham   +5 more
doaj   +1 more source