Results 51 to 60 of about 27,610 (210)

Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms [PDF]

Journal of Antimicrobial Chemotherapy, 2002
Fluconazole alone does not demonstrate any contact activity against resistant organisms. Phenolic antioxidants, such as butylated hydroxyanisole, appear to promote fluconazole activity resulting in the killing of 10(4) cfu/mL of 11 resistant Candida albicans strains within 3-15 min and of 10(4) cfu/mL of 10 resistant Escherichia coli strains within 6 ...
SIMONETTI, Giovanna, VILLA, Adelaide, SIMONETTI, Nicola   +2 more
openaire   +4 more sources

Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium. [PDF]

, 2018
<p>is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, the acquisition of antifungal resistance and potential clonal spread of were explored at a single ...
K. Lagrou, Spriet, Isabel, Isabel Spriet, P. Becker, Berdieke Goemaere, Marijke Hendrickx, Pierre Becker, Lagrou, Katrien, Hendrickx, Marijke, M. Hendrickx, Goemaere, Berdieke, Becker, Pierre, I. Spriet, Katrien Lagrou, B. Goemaere   +14 more
core   +1 more source

Correlation between ERG11 Gene Mutations and Fluconazole Resistance in Candida albicans Strains Isolated from Rasht in Years 2015-2016 [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Candida albicans as an opportunistic fungal pathogen in human causes candidiasis. The widespread use of azoles has led to the increase of azole resistance in Candida albicans isolates.
Saeedeh Balabandi, Zeinab Khazaei-Koohpar, Najmeh Ranji   +2 more
doaj  

Fluconazole Resistance among Oral Candida Isolates from People Living with HIV/AIDS in a Nigerian Tertiary Hospital

Journal of Fungi, 2017
Oropharyngeal candidiasis, a common fungal infection in people living with HIV/AIDS (PLWHA), arises from Candida species colonizing the oral cavity. Fluconazole is the preferred treatment and is often used empirically.
Iriagbonse I. Osaigbovo, Patrick V. Lofor, Rita O. Oladele   +2 more
doaj   +1 more source

Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates

Saudi Pharmaceutical Journal, 2022
Candida species have a major role in nosocomial infections leading to high morbidity and mortality. Increased resistance to various antifungals, especially azoles is a significant problem.
Amira M. El-Ganiny, Hend A. Kamel, Nehal E. Yossef, Basem Mansour, Ahmed M. El-Baz   +4 more
doaj   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

mSphere, 2023
Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals.
Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham   +5 more
doaj   +1 more source

Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum [PDF]

Antimicrobial Agents and Chemotherapy, 1997
An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described. Isolates obtained from blood during therapy showed a progressive increase in fluconazole MIC from 0.625 to 20 micrograms/ml. The pretreatment, or parent, isolate and the posttreatment, or relapse,
J, Wheat, P, Marichal, H, Vanden Bossche, A, Le Monte, P, Connolly   +4 more
openaire   +2 more sources

Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter [PDF]

, 2003
An unusual interaction between flucytosine and fluconazole was observed when a collection of 60 Candida lusitaniae clinical isolates was screened for cross-resistance.
Noël, Thierry, Paumard, Patrick, Villard, Jean, Chastin, Christiane, François, Fabienne, Brèthes, Daniel   +5 more
core   +1 more source

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source