Results 51 to 60 of about 2,213,888 (211)

Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa. [PDF]

, 2013
OBJECTIVES: Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at antiretroviral-therapy (ART) initiation and pre-emptively treating those testing positive.
Thomas S Harrison, Wood, R, Meintjes, Graeme, Joseph N. Jarvis, Joseph N. Jarvis (435279), Harrison Thomas S., Lawn, Stephen D, Cleary, Susan, Robin Wood, Joseph N Jarvis, Stephen D Lawn, Jarvis, JN, Jarvis Joseph N., Meintjes Graeme, Thomas S. Harrison (222993), Graeme Meintjes (221054), Stephen D. Lawn (116037), Robin Wood (4924), Lawn Stephen D., Susan Cleary, Susan Cleary (158497), Stephen D. Lawn, Harrison, Thomas S, Cleary, S, Wood Robin, Harrison, TS, Thomas S. Harrison, Cleary Susan, Lawn, SD, Graeme Meintjes, Meintjes, G, Jarvis, Joseph N, Wood, Robin   +32 more
core   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates

Saudi Pharmaceutical Journal, 2022
Candida species have a major role in nosocomial infections leading to high morbidity and mortality. Increased resistance to various antifungals, especially azoles is a significant problem.
Amira M. El-Ganiny, Hend A. Kamel, Nehal E. Yossef, Basem Mansour, Ahmed M. El-Baz   +4 more
doaj   +1 more source

A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris

mSphere, 2020
The recently emerged pathogenic yeast Candida auris is a major concern for human health, because it is easily transmissible, difficult to eradicate from hospitals, and highly drug resistant. Most C.
Eva-Maria Mayr, Bernardo Ramírez-Zavala, Ines Krüger, Joachim Morschhäuser   +3 more
doaj   +1 more source

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

mSphere, 2023
Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals.
Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham   +5 more
doaj   +1 more source

Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum [PDF]

Antimicrobial Agents and Chemotherapy, 1997
An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described. Isolates obtained from blood during therapy showed a progressive increase in fluconazole MIC from 0.625 to 20 micrograms/ml. The pretreatment, or parent, isolate and the posttreatment, or relapse,
J, Wheat, P, Marichal, H, Vanden Bossche, A, Le Monte, P, Connolly   +4 more
openaire   +2 more sources

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Effect of Potassium on Saccharomyces cerevisiae Resistance to Fluconazole [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT Susceptibility of strain S288c of Saccharomyces cerevisiae to fluconazole was assayed in the presence and absence of KCl. Addition of 150 mM KCl renders the strain more sensitive to the antifungal agent.
Stella, Carlos Alberto, Burgos, Hilda Isabel   +1 more
openaire   +3 more sources

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source