Results 51 to 60 of about 27,453 (182)

Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum [PDF]

Antimicrobial Agents and Chemotherapy, 1997
An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described. Isolates obtained from blood during therapy showed a progressive increase in fluconazole MIC from 0.625 to 20 micrograms/ml. The pretreatment, or parent, isolate and the posttreatment, or relapse,
J, Wheat, P, Marichal, H, Vanden Bossche, A, Le Monte, P, Connolly   +4 more
openaire   +2 more sources

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]

, 2010
Peer ...
Mullick, Alaka, Malcolm Whiteway, Jansen, Gregor, Whiteway, Malcolm, David Y Thomas, Harcus Doreen, Lee Anna Y., Vanier, Ghyslaine, Lee, Anna Y., Thomas, David Y, Michael Hallett, Vanier Ghyslaine, Munro, Carol A., Elias Epp, Epp Elias, Gregor Jansen, Thomas, David Y., Ghyslaine Vanier, Jansen Gregor, Harcus, Doreen, Anna Y Lee, Alaka Mullick, Hallett, Michael, Lee, Anna Y, Thomas David Y., Hallett Michael, Whiteway Malcolm, Carol A Munro, Mullick Alaka, Epp, Elias, Don C Sheppard, Sheppard Don C., Munro Carol A., Doreen Harcus, Sheppard, Don C, Sheppard, Don C., Munro, Carol A   +36 more
core   +1 more source

Effect of Potassium on Saccharomyces cerevisiae Resistance to Fluconazole [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT Susceptibility of strain S288c of Saccharomyces cerevisiae to fluconazole was assayed in the presence and absence of KCl. Addition of 150 mM KCl renders the strain more sensitive to the antifungal agent.
Stella, Carlos Alberto, Burgos, Hilda Isabel   +1 more
openaire   +3 more sources

Fluconazole resistance in various hospital isolates (n = 636).

, 2023
Fluconazole resistance in various hospital isolates (n = 636).
Sidrah Saleem (13807735), Ali Amar (4067920), Faiqa Arshad (17277177), Muhammad Imran (282621), Zill-e- Huma (13808934), Kokab Jabeen (17277174)   +5 more
core   +1 more source

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal.

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source

The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates

Memorias do Instituto Oswaldo Cruz, 2012
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C.
Débora Alves Nunes Mario, Laura Bedin Denardi, Laíssa Arévalo Bandeira, Milene Silva Antunes, Janio Morais Santurio, Luiz Carlos Severo, Sydney Hartz Alves   +6 more
doaj   +1 more source

Potent In Vitro Synergism of Fluconazole and Osthole against Fluconazole-Resistant Candida albicans [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT Osthole is a natural coumarin that exhibits wide biological and pharmacological activities such as neuroprotective, osteogenic, immunomodulation, antitumor, and anti-inflammatory effects. In this study, we investigated the antifungal effects of osthole in vitro . A checkerboard microdilution assay
De-Dong, Li, Dong, Chai, Xiao-Wen, Huang, Shao-Xing, Guan, Jiang, Du, Hao-Yu, Zhang, Yan, Sun, Yuan-Ying, Jiang   +7 more
openaire   +2 more sources

Ketorolac-fluconazole: A New Combination Reverting Resistance in Candida albicans from Acute Myeloid Leukemia Patients on Induction Chemotherapy: In vitro Study

, 2021
Shereen A Sayed,1 Ehsan AB Hassan,2 Muhamad R Abdel Hameed,3 Michael N Agban,2 Mostafa F Mohammed Saleh,3 Hayam H Mohammed,4 Abu-Baker M Abdel-Aal,5 Sherein G Elgendy2 1Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Assiut ...
Abdel-Aal ABM, Elgendy SG, Sayed SA, Hassan EAB, Mohammed HH, Abdel Hameed MR, Agban MN, Mohammed Saleh MF   +7 more
core  

Detection of antifungal drug-resistant and ERG11 gene mutations among clinical isolates of Candida species isolated from Khartoum, Sudan. [version 2; peer review: 2 approved, 1 not approved]

F1000Research, 2021
Background: Candida species are one of the most important opportunistic fungal pathogens that cause both superficial and systemic infections, especially in immunocompromised individuals.
Ahmed Osman Mohamed, Malik Suliman Mohamed, Mohamed Abdelrahman Hussain, Ibrahim Fatahalrahman Ahmed   +3 more
doaj   +1 more source