Results 81 to 90 of about 41,055 (201)

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
doaj   +1 more source

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source

Interactions between copy number and expression level of genes involved in fluconazole resistance in Candida glabrata

Frontiers in Cellular and Infection Microbiology, 2013
Objectives. This study aimed to elucidate the relative involvement of drug resistance gene copy number and overexpression in fluconazole resistance in clinical C. glabrata isolates using a population-based approach. Methods. Fluconazole resistance levels
Salma eAbbes, Hayet eSellami, Annie eMichel-Nguyen, Ali eAyadi, Stéphane eRanque, Stéphane eRanque   +5 more
doaj   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, EarlyView.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Phenotypic and genomic characterization of azole resistance in Portuguese Candida parapsilosis isolates

Frontiers in Fungal Biology
IntroductionCandida parapsilosis is a clinically important etiological agent of systemic infections associated with hospital outbreaks, which prevalence has been increasing in the last decade.
Alexandru-Marian Papuc, Cristina Veríssimo, Helena Simões, Cristina Toscano, João Paulo Gomes, João Paulo Gomes, Verónica Mixão, Raquel Sabino, Raquel Sabino, Raquel Sabino   +9 more
doaj   +1 more source

Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata

mSphere, 2018
The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis.
Sarah G. Whaley, Kelly E. Caudle, Lucia Simonicova, Qing Zhang, W. Scott Moye-Rowley, P. David Rogers   +5 more
doaj   +1 more source

Fungal biofilm resistance [PDF]

, 2012
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +3 more
core   +4 more sources

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

The trend of susceptibilities to amphotericin B and fluconazole of Candida species from 1999 to 2002 in Taiwan

BMC Infectious Diseases, 2005
Background Candida species have various degrees of susceptibility to common antifungal drugs. The extent of resistance to amphotericin B and fluconazole of Candida glabrata isolates causing candidemia has been reported. Active surveillance may help us to
Cheng Hsiao-Hsu, Li Shu-Ying, Yang Yun-Liang, Lo Hsiu-Jung   +3 more
doaj   +1 more source

The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans. [PDF]

PLoS ONE, 2011
The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis, by the overexpression of genes encoding multidrug efflux pumps or ergosterol biosynthesis enzymes.
Christoph Sasse, Rebecca Schillig, Franziska Dierolf, Michael Weyler, Sabrina Schneider, Selene Mogavero, P David Rogers, Joachim Morschhäuser   +7 more
doaj   +1 more source