Results 91 to 100 of about 10,990 (185)

Diagnosis and management of oral candidosis [PDF]

, 2017
Candida is a fungus (yeast) that is generally regarded as a normal and harmless member of the oral microbiome in humans. Should host defences against these commensals be compromised in any way then Candida can cause clinical signs and symptoms, which ...
Lewis, Michael, Williams, David
core   +2 more sources

Venetoclax‐Based Therapy for Early Relapse in Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Minireview

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Refractory/relapsed acute myeloid leukemia (R/R‐AML) typically exhibits resistance to conventional chemotherapy, resulting in a poor overall therapeutic outcome. Salvage allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the primary treatment option in such patients.
Yufeng Du, Mohammad Arian Hassani, Chunhong Li, Zhijia Zhao, Yikun Liu, Chengtao Zhang, Jinsong Yan   +6 more
wiley   +1 more source

Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Methadone is used in hospitalized children to treat pain and iatrogenic opiate withdrawal. Optimal pediatric dosing for both enteral and intravenous methadone is unknown. We conducted two prospective, multi‐center, open‐label studies to characterize the pharmacokinetics of methadone in the pediatric population.
Kevin M. Watt, Elizabeth J. Thompson, Lisa Lam, Kanecia Zimmerman, Christoph P. Hornik, Andrew M. Atz, Allison Fernandez, Susan R. Hupp, Varsha Bhatt‐Mehta, Daniel K. Benjamin Jr, Ravinder Anand, Michael Cohen‐Wolkowiez, Daniel Gonzalez, P. Brian Smith, Edmund V. Capparelli, the Best Pharmaceuticals for Children Act — Pediatric Trials Network Steering Committee   +15 more
wiley   +1 more source

Safety and tolerability of nevirapine-based antiretroviral therapy in HIV-infected patients receiving fluconazole for cryptococcal prophylaxis: a retrospective cohort study [PDF]

BMC Infectious Diseases, 2005
AbstractBackgroundTo compare the adverse events after initiation of nevirapine-based ART among HIV-infected patients who did not receive fluconazole (group A), received fluconazole 400 mg/week (group B), and received fluconazole 200 mg/day (group C).MethodsA retrospective cohort study was conducted among HIV-infected patients who began NVP-based ART ...
Weerawat Manosuthi, Nopphanath Chumpathat, Achara Chaovavanich, Somnuek Sungkanuparph   +3 more
openaire   +3 more sources

Imidazolium‐Based Ionic Liquids as Antifungal and Antibiofilm Agents Against Candida tropicalis

ChemistrySelect, Volume 11, Issue 4, 28 January 2026.
Candida sp. biofilms, particularly those formed on catheters, represent a major clinical challenge. This study evaluates ionic liquids using an experimental biofilm model, demonstrating significant antifungal activity and biofilm disruption, supporting their potential application as alternative strategies for device‐associated infection control ...
Giovanna de Jesus Agostinetto, Paula Reginatto, Lavínia da Veiga Pereira, Clarissa Piccinin Frizzo, Alexandre Meneghello Fuentefria   +4 more
wiley   +1 more source

392. Evaluation of the Long-Term Tolerability and Efficacy of Fluconazole in Patients With Coccidioidomycosis [PDF]

Open Forum Infectious Diseases, 2018
BACKGROUND: Invasive fungal infections within the United States continue to increase annually and represent a significant cause of morbidity and mortality. Fluconazole is a first-generation triazole antifungal used in the treatment of several fungal infections including coccidioidomycosis. Treatment guidelines for coccidioidomycosis recommend high-dose
openaire   +1 more source

Candida albicans Msi3p, a homolog of the Saccharomyces cerevisiae Sse1p of the Hsp70 family, is involved in cell growth and fluconazole tolerance [PDF]

FEMS Yeast Research, 2012
We investigated the cellular function of Msi3p, belonging to the heat shock protein 70 family, in Candida albicans. The mutant strain tetMSI3 was generated, in which MSI3 was controlled by a tetracycline-repressive promoter, because there is evidence to suggest that MSI3 is an essential gene. We controlled the MSI3 expression level by doxycycline (DOX)
Jun-ichi, Nagao, Tamaki, Cho, Jun, Uno, Keigo, Ueno, Rieko, Imayoshi, Hironobu, Nakayama, Hiroji, Chibana, Hidenori, Kaminishi   +7 more
openaire   +2 more sources

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

PLoS Pathogens
Antimicrobial drug resistance poses a global health threat, requiring a deeper understanding of the evolutionary processes that lead to its emergence in pathogens. Complex evolutionary dynamics involve multiple mutations that can result in cooperative or
Pétra Vande Zande, Cécile Gautier, Nora Kawar, Corinne Maufrais, Katura Metzner, Elizabeth Wash, Annette K Beach, Ryan Bracken, Eli Isael Maciel, Nívea Pereira de Sá, Caroline Mota Fernandes, Norma V Solis, Maurizio Del Poeta, Scott G Filler, Judith Berman, Iuliana V Ene, Anna Selmecki   +16 more
doaj   +1 more source

Perioperative management of septic peritonitis in small animals: A review

Veterinary Surgery, Volume 55, Issue 1, Page 39-58, January 2026.
Abstract Background Septic peritonitis (SP) is a complex, life‐threatening disease, driven by peritoneal inflammation and microbial contamination, requiring timely and dynamic perioperative management. Aims The aim of this review was to synthesize current knowledge on the perioperative management of SP in dogs and cats.
Shana K. O'Marra, Bonnie G. Campbell
wiley   +1 more source

Effect of voriconazole on Candida tropicalis biofilms: Relation with ERG genes expression [PDF]

, 2016
Candida tropicalis has emerged as the third most prevalent fungal pathogens and its ability to form biofilms has been considered one of the most important virulence factors, since biofilms represent high tolerance to antifungal agents.
C Luca De, CA Kumamoto, DW Williams, DW Williams, E Fonseca, EM Kojic, FC Bizerra, GS Baillie, KJ Livak, LJ Douglas, M Negri, M Negri, MA Al-Fattani, Mariana Henriques, NN Mishra, P Eggimann, P Muñoz, P Vandeputte, PK Mukherjee, RJ Kothavade, S Silva, S Silva, S Silva, S Silva, S Silva, SK Fridkin, SP Hawser, Sónia Silva, T Fernandes, Tânia Fernandes   +29 more
core   +1 more source