Age-Related Response to Remimazolam among Older Patients Undergoing Orthopedic Surgery: A Single-Center Prospective Observational Study [PDF]
MedicinaBackground and Objectives: Remimazolam, an ultra-short-acting benzodiazepine, is increasingly used in procedural sedation and general anesthesia. It is characterized by rapid onset of action, inactive metabolites, no delay in recovery, and few adverse ...
Min Suk Chae, Nuri Lee, Hyun Jung Koh
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The neurobehavioral effects of flumazenil in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2021 Flumazenil is choosy and competitive GABA receptor blocker that serves as an antidote to benzodiazepines overdose. Its administration in humans and some animal’s model is connected with nervousness, anxiety responses, or seizures attacks.
Ahmed S. Naser, Yasser M. Albadrany
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Respiratory Failure Requiring Mechanical Ventilation Among Patients Receiving Chlordiazepoxide for Alcohol Withdrawal Symptoms. [PDF]
Acta Anaesthesiol ScandABSTRACT Benzodiazepines are a cornerstone in the treatment of alcohol withdrawal symptoms, although their use is associated with a risk of sedation leading to respiratory depression. This study describes the reasons for and frequency of Intensive Care Unit (ICU) admission, mechanical ventilation, and clinical outcomes for patients receiving symptom ...
Reiter N +5 more
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The effect of midazolam and its reversal flumazenil on sedative and cardiopulmonary variables in sheep [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart.
Ünal YAVUZ, Kerem YENER, Adem ŞAHAN
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The use of flumazenil for benzodiazepine associated respiratory depression in postanesthesia recovery: risks and outcomes [PDF]
Revista Brasileira de Anestesiologia, 2018 Background and objectives The primary aim was to determine risk factors for flumazenil administration during postanesthesia recovery. A secondary aim was to describe outcomes among patients who received flumazenil.
Troy G. Seelhammer +7 more
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Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundBenzodiazepines have a hypnotic/sedative effect through the inhibitory action of γ-aminobutyric acid type A receptor. Flumazenil antagonizes these effects via competitive inhibition, so it has been used to reverse the effect of benzodiazepines.
Yi Jeong Kim +5 more
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Pharmaceuticals, 2023 Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABAA (type A) receptors for benzodiazepine ligands.
Wei-Hsi Chen +8 more
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Is the precipitation of anxiety symptoms associated with bolus doses of flumazenil a barrier to its use at low continuous doses in benzodiazepine withdrawal? [PDF]
, 2022 Introduction: Benzodiazepines (BZDs) are used in the management of anxiety and sleep disorders; however, chronic use is associated with tolerance and dependence.
Basso-Hulse, Gioiamia +4 more
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Acute toxicity events of ivermectin in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Ivermectin is a very safe drug; however, there are many studies on its toxic effects in different animals due to sensitivity, misuse, or accidental overdose.
Tamara K. Al-Najmawi, Muna H. Al-Zubaidy
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Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose [PDF]
Vojnosanitetski Pregled, 2016 Backgound/Aim. Flumazenil is benzodiazepine receptor antagonist. It has been studied for a various indications, including reversal of sedation after surgery or diagnostic procedures, awakening of comatose patients in benzodiazepine overdose, or ...
Đorđević Snežana +4 more
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