Long-term delayed emergence after remimazolam-based general anesthesia: a case report
Background Remimazolam is an ultra-short-acting benzodiazepine anesthetic that is antagonized by flumazenil, and it is typically expected to be applied in anesthesia with the purpose of ensuring early postoperative recovery. We report a case of long-term
Tsubasa Takemori+4 more
doaj +1 more source
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi+3 more
core +2 more sources
Scalable Production of Highly-Sensitive Nanosensors Based on Graphene Functionalized with a Designed G Protein-Coupled Receptor [PDF]
We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding.
Crook, Alexander+10 more
core +4 more sources
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky+21 more
core +3 more sources
Tim double-blind, placebo controlled, study assessed the efficacy and safety of flumazenil, a benzodiazepine antagonist, in reversing diazepam-induced sedation in 60 patients undergoing endoscopy.
Lloyd Sutherland+5 more
doaj +1 more source
Sedation of Wild Pyrenean Capercaillie (Tetrao urogallus aquitanicus) Using Intramuscular Midazolam
Global Positioning System (GPS) tracking offers key information in the study of movement ecology of threatened species. Nevertheless, the placement of GPS devices requires animal capture and handling, which may represent a challenge to the individual’s ...
Olga Nicolás Francisco+9 more
doaj +1 more source
Ammonia : this is not the end but rather the end of the beginning [PDF]
Hepatic encephalopathy (HE) represents a wide spectrum of neurological or neuropsychological symptoms caused by liver disease and/or portosystemic shunts.
Dam, Gitte+2 more
core +1 more source
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura+5 more
doaj +1 more source
Applicability test for reducing noise on PET dynamic images using phantom applying deep image prior [PDF]
Objective Positron emission tomography (PET) allows imaging of patho-physiological information as a form of rate constants from a dynamic image. The rate constant image(s) may be affected from noise on the dynamic image. We introduced an artificial intelligence technique of deep image prior (DIP) to reduce noise on dynamic images.
arxiv
Evaluation of the indiscriminate use of flumazenil in benzodiazepine poisonings registered at a poison center in Brazil [PDF]
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Medicina.Introdução: A intoxicação por medicamentos destaca-se como a principal causa de intoxicações no Brasil.
Jesus, Vinicius Klehm de
core