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Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design. [PDF]

Front Chem, 2022
The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects.
Wang Y, Lin Q, Shi H, Cheng D.
europepmc   +3 more sources

Preparation of Fluorine-18 [PDF]

Journal of Nuclear Science and Technology, 1964
Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
Eiji Shikata
openalex   +3 more sources

Novel Strategies for Fluorine‐18 Radiochemistry [PDF]

Angewandte Chemie International Edition, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90272/1/1106_ftp ...
Agard, Aigbirhio, Banks, Campbell-Verduyn, Carroll, Ermert, Gail, Glaser, Hollingworth, Lee, Li, Mamat, Meldal, Miller, Pike, Pike, Ross, Scott, Shah, Shiue, Teare, Teare, Telu, Wittig   +23 more
core   +6 more sources

Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging. [PDF]

Pharmaceuticals (Basel), 2022
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the ...
Sardana M, Breuil L, Goutal S, Goislard M, Kondrashov M, Marchal E, Besson FL, Dugave C, Wrigley G, Jonson AC, Kuhnast B, Schou M, Tournier N, Elmore CS, Caillé F.   +14 more
europepmc   +2 more sources

Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives. [PDF]

Molecules, 2023
The use of radiolabeled glucose for PET imaging resulted in the most commonly used tracer in the clinic, 2-deoxy-2-[18F]fluoroglucose (FDG). More recently, other radiolabeled sugars have been reported for various applications, including imaging tumors ...
Zhang X, Basuli F, Shi ZD, Shah S, Shi J, Mitchell A, Lai J, Wang Z, Hammoud DA, Swenson RE.   +9 more
europepmc   +2 more sources

Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2. [PDF]

Molecules, 2022
Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer.
Kaur J, Bhardwaj A, Wuest F.
europepmc   +2 more sources

Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes [PDF]

Bioconjugate Chemistry, 2014
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β(+) decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive ...
Orit Jacobson, Xiaoyuan Chen, Dale O. Kiesewetter   +2 more
openaire   +4 more sources

Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18

Molecules, 2013
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch, Constantin Mamat, Marc Pretze   +2 more
doaj   +2 more sources

Fluorine-18 isotope scans of the sacroiliac joints. [PDF]

Annals of the Rheumatic Diseases, 1972
J. Webb, L. Collins, Philip Southwell, J. B. Dick‐Smith   +3 more
openalex   +4 more sources

Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective studyCentral MessagePerspective

JTCVS Open, 2023
Objectives: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography–based prognosis ...
Akira Hamada, MD, PhD, Kazuhiro Kitajima, MD, PhD, Kenichi Suda, MD, PhD, Takamasa Koga, MD, PhD, Junichi Soh, MD, PhD, Hayato Kaida, MD, PhD, Kimiteru Ito, MD, PhD, Tetsuro Sekine, MD, PhD, Kyoshiro Takegahara, MD, PhD, Hiromitsu Daisaki, PhD, Masaki Hashimoto, MD, PhD, Yukihiro Yoshida, MD, PhD, Takanobu Kabasawa, MD, PhD, Takashi Yamasaki, MD, Seiichi Hirota, MD, PhD, Jitsuo Usuda, MD, PhD, Kazunari Ishii, MD, PhD, Tetsuya Mitsudomi, MD, PhD   +17 more
doaj   +1 more source