Preparation of Fluorine-18 [PDF]
Journal of Nuclear Science and Technology, 1964 Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
Eiji Shikata
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Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
Angewandte Chemie International Edition, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90272/1/1106_ftp ...
Agard +23 more
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Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging [PDF]
Pharmaceuticals, 2022 Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the ...
Malvika Sardana +14 more
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Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives [PDF]
Molecules, 2023 The use of radiolabeled glucose for PET imaging resulted in the most commonly used tracer in the clinic, 2-deoxy-2-[18F]fluoroglucose (FDG). More recently, other radiolabeled sugars have been reported for various applications, including imaging tumors ...
Xiang Zhang +9 more
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A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions [PDF]
Chemistry, 2017 Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents.
Aldrich-Wright, J. +10 more
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Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design [PDF]
Frontiers in Chemistry, 2022 The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects.
Yunze Wang +11 more
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Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers [PDF]
Molecules, 2020 Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled radiotracers often requires harsh reaction conditions, limiting the
Sofia Otaru +5 more
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Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 [PDF]
Molecules, 2022 Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer.
Jatinder Kaur +2 more
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Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes [PDF]
Bioconjugate Chemistry, 2014 Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β(+) decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive ...
Orit Jacobson +2 more
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Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non–small‐cell lung cancer patients [PDF]
International Journal of Cancer, 2012 In the recent years, fluorine 18 fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET)/computed tomography (CT) has emerged as a new modality for staging non–small‐cell lung cancer (NSCLC) patients.
Yihua Wu +8 more
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