Results 1 to 10 of about 54,862 (119)

Preclinical evaluation of a fluorine-18-labeled indocyanine green analog for PET imaging of hepatic function [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Accurate assessment of liver function and biliary excretion is a key aspect in the medical and surgical management of various liver conditions.
Khashayar Vakili, Alan Packard
doaj   +2 more sources

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Molecules, 2021
In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson   +4 more
doaj   +1 more source

Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective studyCentral MessagePerspective

JTCVS Open, 2023
Objectives: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography–based prognosis ...
Akira Hamada, MD, PhD, Kazuhiro Kitajima, MD, PhD, Kenichi Suda, MD, PhD, Takamasa Koga, MD, PhD, Junichi Soh, MD, PhD, Hayato Kaida, MD, PhD, Kimiteru Ito, MD, PhD, Tetsuro Sekine, MD, PhD, Kyoshiro Takegahara, MD, PhD, Hiromitsu Daisaki, PhD, Masaki Hashimoto, MD, PhD, Yukihiro Yoshida, MD, PhD, Takanobu Kabasawa, MD, PhD, Takashi Yamasaki, MD, Seiichi Hirota, MD, PhD, Jitsuo Usuda, MD, PhD, Kazunari Ishii, MD, PhD, Tetsuya Mitsudomi, MD, PhD   +17 more
doaj   +1 more source

State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

EJNMMI Radiopharmacy and Chemistry, 2023
Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis.
Lizeth Y. F. Haveman, Danielle J. Vugts, Albert D. Windhorst   +2 more
doaj   +1 more source

Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging

Pharmaceuticals, 2022
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the ...
Malvika Sardana, Louise Breuil, Sébastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caillé   +14 more
doaj   +1 more source

Isotopic Radiolabeling of the Antiretroviral Drug [¹⁸F]Dolutegravir for Pharmacokinetic PET Imaging

Pharmaceuticals, 2022
Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud, Sébastien Goutal, Thomas Bonasera, Maud Goislard, Delphine Desjardins, Roger Le Grand, Chris M. Parry, Nicolas Tournier, Bertrand Kuhnast, Fabien Caillé   +9 more
doaj   +1 more source

Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi

Pharmaceuticals, 2022
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli, Fadi Zarrad, Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont, Alex Jackson, Wolfgang P. Fendler, Ken Herrmann, Michael Nader   +9 more
doaj   +1 more source

Advances in [¹⁸F]Trifluoromethylation Chemistry for PET Imaging

Molecules, 2021
Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo.
Felix Francis, Frank Wuest
doaj   +1 more source

Fluorine-18 Labeled Urea-Based Ligands Targeting Prostate-Specific Membrane Antigen (PSMA) with Increased Tumor and Decreased Renal Uptake

Pharmaceuticals, 2022
High expression of prostate-specific membrane antigen (PSMA) in prostate cancers prompted the development of the PSMA-targeted PET-imaging agent [18F]DCFPyL, which was recently approved by the FDA. Fluorine-18-labeled Lys–Urea–Glu-based oxime derivatives
Falguni Basuli, Tim E. Phelps, Xiang Zhang, Carolyn C. Woodroofe, Jyoti Roy, Peter L. Choyke, Rolf E. Swenson, Elaine M. Jagoda   +7 more
doaj   +1 more source

Importance of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in detection of post-thyroidectomy recurrence in differentiated thyroid cancer with negative radio-isotope iodine scan, yet, elevated serum thyroglobulin level

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background Thyroid cancer considered the 6th common cancer in female and represents approximately 1% of all cancers. Thyroid cancer is generally characterized by good prognosis, long term survival and low aggressiveness. Its prognosis is related to tumor
Amir Fathy Henfy Younis, Ahmed Farid Yousif, Hamada Mohamed Khater   +2 more
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