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Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges

Applied Sciences, 2012
Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies
Carmen Wängler, Alexey Kostikov, Jun Zhu, Joshua Chin, Björn Wängler, Ralf Schirrmacher   +5 more
doaj   +1 more source

Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals-radiosynthesis and ex vivo biodistribution of [18F] 3-(4-(2-(2-(2-fluoroethoxy) ethoxy) ethylthio)-1, 2, 5-thiadiazol-3-yl)-1-methyl-1, 2, 5, 6-tetrahydropyridine [PDF]

, 2010
Muscarinic receptors have been implicated in neurological disorders including Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities ...
Houle, Sylvain, Mamo, David, Mulsant, Benoit H., Pollock, Bruce G., van Oosten, Erik M., Vasdev, Neil, Wilson, Alan A.   +6 more
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Synthesis of fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers by 18 F‐for‐ 19 F exchange [PDF]

, 1990
Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile 18 F‐for‐ 19 F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time ...
Berridge, Boggs, Gens, Ido, Luxen, Mulholland, Mulholland, Sheppard, Subramanian, Tarrant, Tiers   +10 more
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A BORON COMPLEX DESIGNED FOR FLUORINE-18 LABELING AIMING FOR PET IMAGING APPLICATION

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide due to the availability of compact medical cyclotrons and automated chemistry for the production of radiopharmaceuticals.
Mariana Almeida Figueira, Joaldo Garcia Arruda, Victor Maia Miranda, Pedro Paulo Corbi, Luiz Antônio Sodré Costa, Fabio Luiz Navarro Marques, Victor Marcelo Deflon   +6 more
doaj   +1 more source

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Molecules, 2020
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures.
Maxime Munch, Benjamin H. Rotstein, Gilles Ulrich   +2 more
doaj   +1 more source

Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats

Acta Pharmaceutica Sinica B
The translocator protein (TSPO) positron emission tomography (PET) can noninvasively detect neuroinflammation associated with epileptogenesis and epilepsy.
Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng   +11 more
doaj   +1 more source

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

Molecules, 2018
Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva, Stal Shrestha, Prachi Singh, Cheryl L. Morse, Kimberly J. Jenko, Jose A. Montero Santamaria, Sami S. Zoghbi, Robert B. Innis, Victor W. Pike   +8 more
doaj   +1 more source

Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow. [PDF]

, 2008
The utility of PET for monitoring responses to radiation therapy have been complicated by metabolically active processes in surrounding normal tissues.
Agazaryan, Nzhde, Czernin, Johannes, DeMarco, John J, Hsueh, Wei-Ann, Kesner, Adam L, Lau, Victoria K, Silverman, Daniel Hs, Speiser, Michael   +7 more
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Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors

Beilstein Journal of Organic Chemistry, 2017
Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers.
Thomas Lee Collier, Steven H. Liang, J. John Mann, Neil Vasdev, J. S. Dileep Kumar   +4 more
doaj   +1 more source

Prognostic value of metabolic tumor volume of pretreatment 18F-FAMT PET/CT in non-small cell lung Cancer [PDF]

, 2019
学位記番号 ...
Kumasaka, Soma, クマサカ, ソウマ, 熊坂, 創真   +2 more
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