Preparation of Fluorine-18 [PDF]
Journal of Nuclear Science and Technology, 1964 Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
Eiji Shikata
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Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
Angewandte Chemie International Edition, 2011 Positron (b) emission tomography (PET) is a powerful, noninvasive tool for the in vivo, three-dimensional imaging of physiological structures and processes. PET imaging involves the incorporation of short-lived radionuclides, particularly carbon-11 and fluorine-18, into biologically active molecules.
Littich, Ryan, Scott, Peter J. H.
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A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions. [PDF]
Chemistry, 2017 Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents.
M. Klenner +10 more
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Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes [PDF]
Bioconjugate Chemistry, 2014 Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research.
Orit Jacobson +2 more
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Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non–small‐cell lung cancer patients [PDF]
International Journal of Cancer, 2013 In the recent years, fluorine 18 fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET)/computed tomography (CT) has emerged as a new modality for staging non–small‐cell lung cancer (NSCLC) patients.
Yihua Wu +8 more
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Medicine, 2015 To investigate the performance of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/computed tomography (CT) in the diagnosis, staging, restaging, and recurrence surveillance of bone sarcoma by systematically reviewing ...
Fanxiao Liu +7 more
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Fluorine-18 isotope scans of the sacroiliac joints. [PDF]
Annals of the Rheumatic Diseases, 1972 L. T. Collins +3 more
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Positron emission tomography in the diagnosis and follow-up of transthyretin amyloid cardiomyopathy patients:A systematic review [PDF]
, 2023 Purpose: Transthyretin (ATTR) amyloidosis is a progressive protein misfolding disease with frequent cardiac involvement. This review aims to determine the value of PET in diagnosis, assessment of disease progression or treatment response and its relation
Nienhuis, H. L.A. +7 more
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
ACS Chemical Neuroscience, 2020 Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets.
S. Syvänen +7 more
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Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers [PDF]
, 2020 Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled radiotracers often requires harsh reaction conditions, limiting the
Airaksinen, Anu J. +5 more
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