Results 161 to 170 of about 174,614 (242)

A Contrast‐Enhanced Ultrasound Cine‐Based Deep Learning Model for Predicting the Response of Advanced Hepatocellular Carcinoma to Hepatic Arterial Infusion Chemotherapy Combined With Systemic Therapies

Cancer Science, EarlyView.
To the best of our knowledge, this is the first prospective study to develop a non‐invasive imaging‐based deep learning model to predict the therapeutic response of advanced HCC to HAIC triple combination therapy in a dual‐center cohort. We developed and externally validated an attention‐enhanced three‐dimensional deep convolutional neural network ...
Xu Han, Chuan Peng, Si‐Min Ruan, Lingling Li, Minke He, Ming Shi, Bin Huang, Yudi Luo, Jingming Liu, Huiying Wen, Wei Wang, Jianhua Zhou, Minhua Lu, Xin Chen, Ruhai Zou, Zhong Liu   +15 more
wiley   +1 more source

Repigmentation of vitiligo with 5-fluorouracil tattooing in combination with topical ruxolitinib: A case report. [PDF]

JAAD Case Rep
Macit B, Burns L, Wambier CG.
europepmc   +1 more source

TGF‐β Enhances Doxorubicin Resistance and Anchorage‐Independent Growth in Cancer Cells by Inducing ALDH1A1 Expression

Cancer Science, EarlyView.
We have demonstrated that prestimulation of human lung cancer cells with TGF‐β enhances resistance to doxorubicin‐induced growth inhibition, depending on Smad3 and Smad4 through induction of ALDH1A1. Knockdown of ALDH1A1 suppressed TGF‐β‐induced resistance to doxorubicin, and exogenous expression of ALDH1A1 in SMAD3‐KO cells restored the drug ...
Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa   +2 more
wiley   +1 more source

First-line treatment of anti-EGFR monoclonal antibody cetuximab β plus FOLFIRI versus FOLFIRI alone in Chinese patients with RAS/BRAF wild-type metastatic colorectal cancer: a randomized, phase 3 trial. [PDF]

Signal Transduct Target Ther
Shi Y, Ba Y, Wang J, Xiong J, Gu K, Chen Y, Zheng Z, Wang Z, Guo W, Cheng Y, Yin X, Liu Y, Bai Y, Li E, Li Q, Zhu L, Li W, Jiang D, He J, Chen J, Sun J, Hou S.   +21 more
europepmc   +1 more source

Long‐Term Morphological Changes of Crosslinked Gelatin Stent

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This study investigates the long‐term morphological outcomes of crosslinked gelatin stents over a 10‐year period. Methods Participants from the FDA phase 1 and 2 trials for the XEN 140 stent were recalled for follow‐up examinations between 9 and 12 years after their initial implantation.
Yuen Keat Gan, Hong Kee Ng, William H. Morgan, Dao‐Yi Yu   +3 more
wiley   +1 more source

Soft tissue metastasis in colorectal cancer: a case report. [PDF]

J Med Case Rep
Zenzri Y, Ghodhbani Z, Yacoub H, Houcine Y, Ben Mansour H, Meddeb K, Maamouri N, Mezlini A.   +7 more
europepmc   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Exploratory Analysis of Molecular Subtypes in Early-Stage Osteosarcoma: Identifying Resistance and Optimizing Therapy. [PDF]

Cancers (Basel)
Bojic L, Peric M, Karanovic J, Milosevic E, Kovacevic Grujicic N, Milivojevic M.   +5 more
europepmc   +1 more source

Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects

Cell Proliferation, EarlyView.
The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang, Zhong Chu, Shuwen Han, Yuefen Pan   +3 more
wiley   +1 more source

Advances in the treatment of unresectable locally advanced esophageal squamous carcinoma (Review). [PDF]

Mol Clin Oncol
Wang L, Xu Z, Sun M, He H, Li Z.
europepmc   +1 more source