Results 161 to 170 of about 192,487 (273)

Phase II study of magrolimab combination therapies in patients with head and neck squamous-cell carcinoma. [PDF]

ESMO Open
Colevas AD, Chin V, Park JJ, Adkins D, Phan M, Fang B, Forget F, Amorim J, Misiukiewicz K, Costa DA, Rainey N, Even C, Wong DJ, Kerrigan K, Zhang Y, Dong M, Rong R, Caldwell K, Leung C, Dinis J.   +19 more
europepmc   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Phase II study of FOLFIRI with low-dose irinotecan plus ramucirumab as second-line treatment in Japanese patients with metastatic colorectal cancer (study rindo). [PDF]

Jpn J Clin Oncol
Hattori N, Nakayama G, Umeda S, Kishida T, Takeda S, Ezaka K, Tsutsuyama M, Sakai M, Hattori M, Ito T, Kanda M, Tanaka C, Murotani K, Ando M, Kodera Y.   +14 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Battle against time for innovative cancer treatment: an updated cost-effectiveness analysis of pemigatinib in intrahepatic cholangiocarcinoma. [PDF]

Cost Eff Resour Alloc
Wang IT, Chen HL, Huang WM, Chiang NJ, Shen LJ, Chueh CH, Tsai YW.   +6 more
europepmc   +1 more source

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

The Laryngoscope, EarlyView.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian, Inabat Yermesheva, Ostap Orishchak, Hady Tall, Sam J. Daniel   +4 more
wiley   +1 more source

Upfront Modified FOLFOXIRI Plus Panitumumab for <i>RAS/BRAF</i> Wild-Type Metastatic Colorectal Cancer: Final Results of the Phase III TRIPLETE Study. [PDF]

J Clin Oncol
Conca V, Rossini D, Antoniotti C, Lonardi S, Pietrantonio F, Moretto R, Antonuzzo L, Randon G, Lavacchi D, Pozzo C, Marmorino F, Bergamo F, Tamburini E, Passardi A, Fazio R, Murgioni S, Borelli B, Buonadonna A, Germani MM, Formica V, Carullo M, Bordonaro R, Aprile G, Zaniboni A, Masi G, Boni L, Cremolini C.   +26 more
europepmc   +1 more source

Clinical and Histopathological Assessment of the Field of Cancerization in Human Skin Before and After Treatment With a 1927‐nm Thulium Fractional Laser

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Background Field cancerization is a major concern in photodamaged skin due to its risk of progression to squamous cell carcinoma. The 1927‐nm thulium laser has emerged as a promising therapy, but its isolated effects on this condition remain underexplored.
Livia Maria Oliveira Salviano, André Bubna Hirayama, Marcella Soares Pincelli, Vivian Nunes Arruda, Rodrigo Cesar Davanço, Luiza Reis Pinto, Luis Antonio Ribeiro Torezan   +6 more
wiley   +1 more source

Acute Gout Flare After Carboplatin/5-Fluorouracil for Locally Advanced Head and Neck Squamous Cell Carcinoma. [PDF]

Cancer Rep (Hoboken)
Zou H, Janadi AA, Sako Z.
europepmc   +1 more source

Analysis of the Matrix Metalloproteinases Family Profile in Gastric Cancer Suggests Key Matrix Metalloproteinases for Tumor Development and Their Clinical Impact

Molecular Carcinogenesis, EarlyView.
ABSTRACT Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC.
Aline Costa Bastos, André Salim Khayat, Emanuele Raimunda Louzada Moraes, Ágatha Tereza Miranda Tavares, Ronald Matheus da Silva Mourão, Fabiano Cordeiro Moreira, Samir Mansour Moraes Casseb, Samia Demachki, Geraldo Ishak, Williams Fernandes Barra, Rommel Mario Rodríguez Burbano, Paulo Pimentel de Assumpção   +11 more
wiley   +1 more source