Results 1 to 10 of about 13,842 (142)

A Prime-Boost Vaccination Strategy in Cattle to Prevent Foot-and-Mouth Disease Using a "Single-Cycle" Alphavirus Vector and Empty Capsid Particles. [PDF]

PLoS ONE, 2016
Foot-and-mouth disease (FMD) remains one of the most economically important infectious diseases of production animals globally. Vaccination can successfully control this disease, however, current vaccines are imperfect.
Maria Gullberg, Louise Lohse, Anette Bøtner, Gerald M McInerney, Alison Burman, Terry Jackson, Charlotta Polacek, Graham J Belsham   +7 more
doaj   +6 more sources

Cmss1 limits FMDV infection by enhancing antigen presentation and CD8+ T cell responses [PDF]

Journal of Virology
The foot and mouth disease virus (FMDV) poses a heavy burden on the global swine industry, underscoring the urgent need for long-term protective vaccines to control FMDV infection.
Yang Wang, Lihong Zhang, Jieru Deng, Linlin Zheng, Zhihua Chen, Zhao Zhang, Han Zhang, Jingjing Pei, Haixue Zheng   +8 more
doaj   +2 more sources

Foot-and-mouth disease virus 3D polymerase antagonizes the interferon signaling pathway by blocking STAT2 nuclear translocation [PDF]

Virus Research
Foot-and-mouth disease virus (FMDV) is the etiological agent of foot-and-mouth disease (FMD), which is highly contagious and extremely destructive in cloven-hoofed animals.
Kangli Li, Boning Zhu, Shuo Wang, Xiangle Zhang, Xiaodan Wen, Weijun Cao, Guoliang Zhu, Haixue Zheng, Fan Yang, Zixiang Zhu   +9 more
doaj   +2 more sources

Molecular and serological typing of foot-and-mouth disease virus serotypes currently circulating in Egypt [PDF]

Iraqi Journal of Veterinary Sciences, 2021
Foot-and-mouth disease (FMD) is an extremely contagious viral disease affects all cloven- hoofed animals. The present study aimed to investigate the epidemiological situation of FMD in Egypt during 2017 and 2018, based on antigenic and genetic ...
Maryam M. ِbd El-Rhman, Sayed A. Salem, Abdel-Hamid I. Bazid, Diea J. Abo El-Hassan   +3 more
doaj   +1 more source

Preparation and Characterization of Nanoliposome Containing Isolated VP1 Protein of Foot and Mouth Disease Virus as a Model of Vaccine [PDF]

Archives of Razi Institute, 2022
Foot-and-mouth disease (FMD) is an acute and highly contagious disease in livestock, such as cattle, sheep, and pigs, leading to a lot of economic losses.
M Kazemi, R Madani, M. R Aghamaali, T Emami, F Golchinfar, L Heshmati   +5 more
doaj   +1 more source

An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein

Cell Reports, 2022
Summary: The foot-and-mouth disease virus (FMDV) 2C protein shares conserved motifs with enterovirus 2Cs despite low sequence identity. Here, we determine the crystal structure of an FMDV 2C fragment to 1.83 Å resolution, which comprises an ATPase domain,
Chu Zhang, Fan Yang, Justyna Aleksandra Wojdyla, Bo Qin, Wei Zhang, Min Zheng, Weijun Cao, Meitian Wang, Xiaopan Gao, Haixue Zheng, Sheng Cui   +10 more
doaj   +1 more source

A Single Dose of Dendrimer B₂T Peptide Vaccine Partially Protects Pigs against Foot-and-Mouth Disease Virus Infection

Vaccines, 2020
Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported that dendrimer peptide B2T, with two copies of FMDV B-cell epitope VP1 (136−154) linked ...
Rodrigo Cañas-Arranz, Mar Forner, Sira Defaus, Patricia de León, María J. Bustos, Elisa Torres, Francisco Sobrino, David Andreu, Esther Blanco   +8 more
doaj   +1 more source

High-Resolution Composition Analysis of an Inactivated Polyvalent Foot-and-Mouth Disease Vaccine

Pathogens, 2020
Appropriate vaccine selection is crucial in the control of foot-and-mouth disease (FMD). Vaccination can prevent clinical disease and reduces viral shedding, but there is a lack of cross-protection between the seven serotypes and their sublineages ...
Leonie F. Forth, Dirk Höper, Martin Beer, Michael Eschbaumer   +3 more
doaj   +1 more source

Analysis of Foot and Mouth Disease Virus Polyprotein for Multi Peptides Vaccine Design: An In silico Strategy

Journal of Pure and Applied Microbiology, 2022
Foot-and-mouth disease virus (FMDV) is small RNA virus from Picornaviridae family; genus Aphthovirus. FMDV causes maximum levels of infectivity in cattle and harmful socioeconomic effects. The present report attempted to design vaccine candidate from the
Ranya Mohmed Sid Ahmed, Yassir A. Almofti, Khoubieb Ali Abd-elrahman   +2 more
doaj   +1 more source

Into the Deep (Sequence) of the Foot-and-Mouth Disease Virus Gene Pool: Bottlenecks and Adaptation during Infection in Naïve and Vaccinated Cattle

Pathogens, 2020
Foot-and-mouth disease virus (FMDV) infects hosts as a population of closely related viruses referred to as a quasispecies. The behavior of this quasispecies has not been described in detail in natural host species. In this study, virus samples collected
Ian Fish, Carolina Stenfeldt, Rachel M. Palinski, Steven J. Pauszek, Jonathan Arzt   +4 more
doaj   +1 more source