Results 11 to 20 of about 18,308 (279)
FMDV replicons encoding green fluorescent protein are replication competent [PDF]
Journal of Virological Methods, 2014 The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by
Angus I. Lamond +28 more
core +10 more sources
Protein coexpression using FMDV 2A : effect of “linker” residues [PDF]
BioMed Research International, 2013 This article was made open access through BIS OA funding. The research was supported by the MRC.Many biomedical applications absolutely require, or are substantially enhanced by, coexpression of multiple proteins from a single vector.
Minskaia, Ekaterina, Ryan, Martin D.
core +8 more sources
DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3.
Cellular Signalling, 2019 The components of foot-and-mouth disease virus (FMDV) interact with host cellular proteins to promote self-replication and evade the host immune response. Previous studies have shown that FMDV 3A, 2C and 2B proteins interact with host cellular proteins involved in FMDV replication.
Shaozu Fu +7 more
semanticscholar +4 more sources
Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1 [PDF]
Veterinary Research, 2014 Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV).
Chunsheng Yin +9 more
semanticscholar +4 more sources
Functional advantages of triplication of the 3B coding region of the FMDV genome [PDF]
The FASEB Journal, 2020 For gene duplication to be maintained, particularly in the small genomes of RNA viruses, this should offer some advantages. We have investigated the functions of a small protein termed VPg or 3B, which acts as a primer in the replication of foot‐and ...
O. Adeyemi +5 more
semanticscholar +5 more sources
Virus-like particles of recombinant PCV2b carrying FMDV-VP1 epitopes induce both anti-PCV and anti-FMDV antibody responses [PDF]
Applied Microbiology and Biotechnology, 2018 Mixed infection of porcine circovirus type 2 (PCV2) and foot-and-mouth disease virus (FMDV) is devastating to swine populations. To develop an effective vaccine that can protect the pigs from the infection of PCV2 and FMDV, we used the neutralizing B cell epitope region (aa 135-160) of FMDV to replace the regions aa 123-151 and aa 169-194 of the PCV2b ...
Xin Li +10 more
semanticscholar +4 more sources
IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals [PDF]
BMC Veterinary Research, 2016 BackgroundFoot-and-mouth disease virus (FMDV) possess a positive sense, single stranded RNA genome. Internal ribosomal entry site (IRES) element exists within its 5′ untranslated region (5′UTR) of the viral RNA.
Takehiro Kanda +2 more
semanticscholar +4 more sources
Virology, 2012 Picornavirus infection can lead to disruption of nuclear pore traffic, shut-off of cell translation machinery, and cleavage of proteins involved in cellular signal transduction and the innate response to infection. Here, we demonstrated that the FMDV 3C(pro) induced the cleavage of nuclear RNA-binding protein Sam68 C-terminus containing the nuclear ...
P. Lawrence, E. Schafer, E. Rieder
semanticscholar +4 more sources
Location and characterization of the antigenic portion of the FMDV immunizing protein.
Journal of General Virology, 1982 Purified foot-and-mouth disease virus (FMDV) to type O1K was treated with several endopeptidases of differing specificity. The immunizing protein VPThr was cleaved into two detectable fragments by all enzymes except for glutamic acid-specific ...
K. Strohmaier, R. Franze, K. Adam
semanticscholar +3 more sources
PLoS ONE, 2011 Mucosal vaccination has been demonstrated to be an effective means of eliciting protective immunity against aerosol infections of foot and mouth disease virus (FMDV) and various approaches have been used to improve mucosal response to this pathogen.
G. Wang +8 more
semanticscholar +6 more sources