Results 71 to 80 of about 6,156 (251)

Beneficial effect of voluntary exercise on experimental colitis in mice fed a high-fat diet : the role of irisin, adiponectin and proinflammatory biomarkers [PDF]

, 2017
Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn‘s disease and ulcerative colitis.
Bilski, Jan, Brzozowski, Bartosz, Brzozowski, Tomasz, Chmura, Anna, Hubalewska-Mazgaj, Magdalena, Mach, Tomasz, Magierowska, Katarzyna, Magierowski, Marcin, Mazur-Biały, Agnieszka, Surmiak, Marcin, Wójcik, Dagmara   +10 more
core   +1 more source

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

Stem Cell Research & Therapy, 2021
Background Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI repair.
Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang, Zheng Zhang   +7 more
doaj   +1 more source

The effect of exercise interventions on Irisin level

EXCLI Journal : Experimental and Clinical Sciences, 2022
Irisin is a hormone that is offered to be a hopeful remedial target in obesity and type 2 diabetes. It has received striking attention recently, whereas, the interactions between exercise training and irisin are still unclear.
Gholam Rasul Mohammad Rahimi, Keyvan Hejazi, Martin Hofmeister   +2 more
doaj   +1 more source

FNDC5: A novel player in metabolism and metabolic syndrome

Biochimie, 2019
Half a decade ago, transmembrane protein fibronectin type III domain-containing protein 5 (FNDC5) was found to be cleaved as a novel myokine irisin, which burst into prominence for browning of white adipose tissue during exercise. However, FNDC5, the precursor of irisin, has been paid relatively little attention compared with irisin despite evidence ...
Richard Y. Cao, Hongchao Zheng, Damian Redfearn, Jian Yang   +3 more
openaire   +3 more sources

Prepontine non-giant neurons drive flexible escape behavior in zebrafish [PDF]

, 2019
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.
Bergeron, S., Briggman, K., Burgess, H., Marquart, G., Tabor, K.   +4 more
core   +2 more sources

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Journal of Translational Medicine, 2019
Background Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (FNDC5) in cardiac inflammation and ...
Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou, Xiao-Qing Xiong   +6 more
doaj   +1 more source

Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High‐Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid‐Beta (Aβ) Plaque Formation in the Hippocampus of Aβ‐Induced Alzheimer's Disease Rats [PDF]

CNS Neurosci Ther
Samira Puoyan‐Majd, Abdolhossein Parnow, Masome Rashno, Rashid Heidarimoghadam, Alireza Komaki‬   +4 more
openalex   +2 more sources

Evolutionary Insights into Irisin/FNDC5: Roles in Aging and Disease from Drosophila to Mammals [PDF]

Biomolecules
Kiwon Lee, Myungjin Kim
openalex   +2 more sources

The alteration of irisin - brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients [PDF]

, 2017
Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma.
Fodor, Andrea, Gesztelyi, Rudolf, Kardos, László, Mikáczó, Angéla, Papp, Csaba, Pák, Krisztián, Seres, Ildikó, Szilasi, Magdolna Emma, Szilasi, Mária, Tajti, Gábor, Varga, Viktória Evelin, Zsuga, Judit   +11 more
core   +2 more sources

Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1

Aging Cell
Postmenopausal osteoporosis is a prevalent metabolic bone disorder characterized by a decrease in bone mineral density and deterioration of bone microstructure. Despite the high prevalence of this disease, no effective treatment for osteoporosis has been
Lin Tao, Jinpeng Wang, Ke Wang, Qichang Liu, Hongyang Li, Site Xu, Chunjian Gu, Yue Zhu   +7 more
semanticscholar   +1 more source