Results 71 to 80 of about 5,116 (221)
Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
Frontiers in Pharmacology, 2019 ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li +24 more
doaj +1 more source
Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression [PDF]
Physiological Reports, 2015 Fibronectin type III domain-containing protein 5 (FNDC5) expression is controlled by the transcriptional co-activator, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α). FNDC5 expression has been shown to be increased in muscle in response to endurance exercise in some but not all studies, therefore a greater understanding ...
Lally, JSV +5 more
openaire +4 more sources
Experimental Physiology, EarlyView.Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su +4 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibronectin type III domain-containing protein 5 (FNDC5), also known as irisin, is a myokine secreted from muscle in response to exercise.
Xiu-ying Yang +5 more
doaj +1 more source
FNDC5 is produced in the stomach and associated to body composition [PDF]
Scientific Reports, 2016 AbstractThe fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach.
S. Barja-Fernández +9 more
openaire +3 more sources
Integrative physiology of skeletal muscle for maintaining cognitive health
The Journal of Physiology, EarlyView.Abstract figure legend Maintenance of brain/cognitive health and function is increasingly appreciated to be a systemic challenge. In particular, skeletal muscle influences the brain through release of myokines in response to contraction, which influence the expression of brain‐derived neurotrophic factor (BDNF) in the brain, a vital player in the ...
Matthew H. Brisendine, Joshua C. Drake
wiley +1 more source
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
eneuro, 2023 AbstractMajor depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III
Ricardo Lima-Filho +9 more
openaire +2 more sources
The central benefit of physiologically induced ketogenic states
The Journal of Physiology, EarlyView.Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley +1 more source
The effects of resistance training, testosterone and palm (Phoenix dactylifera L.) pollen extract on the expression of FNDC5 and IGF1 genes in brown adipose tissue in male rats [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background and Aim: The use of testosterone enanthate is popular among athletes, especially resistance sports. Considering the side effects of using testosterone enanthate, it seems necessary to find alternative methods.
Ali Arbati +3 more
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