Results 61 to 70 of about 1,381,729 (387)
The mechano-chemistry of cytoskeletal force generation [PDF]
, 2014 In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as ...
Garikipati, Krishna, Maraldi, Mirko
core +1 more source
The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
Journal of experimental & clinical cancer research : CR, 2019 FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling ...
Jin Zhou, Qian Yi, Liling Tang
semanticscholar +1 more source
Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions [PDF]
, 2016 Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy.
Dedecker, Peter +10 more
core +2 more sources
PLoS ONE, 2012 The speed of cell migration on 2-dimensional (2D) surfaces is determined by the rate of assembly and disassembly of clustered integrin receptors known as focal adhesions.
Jessie Zhong +7 more
doaj +1 more source
Journal of experimental & clinical cancer research : CR, 2019 Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells.
D. Rigiracciolo +11 more
semanticscholar +1 more source
Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. [PDF]
PLoS ONE, 2012 ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell ...
Frances E Lock +4 more
doaj +1 more source
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
openaire +3 more sources
Wound-induced polyploidization is dependent on Integrin-Yki signaling
Biology Open, 2021 A key step in tissue repair is to replace lost or damaged cells. This occurs via two strategies: restoring cell number through proliferation or increasing cell size through polyploidization.
Rose Besen-McNally +2 more
doaj +1 more source
Omics approaches to identify potential biomarkers of inflammatory diseases in the focal adhesion complex [PDF]
, 2017 Inflammatory diseases such as inflammatory bowel disease require recurrent invasive tests, including blood tests, radiology and endoscopic evaluation for diagnosis, assessment of disease activity and to determine optimal therapeutic strategies. ‘Bedside’
Ab Mutalib +81 more
core +2 more sources
Investigation of the limits of nanoscale filopodial interactions [PDF]
, 2014 Mesenchymal stem cells are sensitive to changes in feature height, order and spacing. We had previously noted that there was an inverse relationship between osteoinductive potential and feature height on 15-, 55- and 90 nm-high titania nanopillars, with ...
Dalby, Matthew J. +5 more
core +2 more sources