Results 61 to 70 of about 1,259,124 (381)

Investigation of the limits of nanoscale filopodial interactions [PDF]

, 2014
Mesenchymal stem cells are sensitive to changes in feature height, order and spacing. We had previously noted that there was an inverse relationship between osteoinductive potential and feature height on 15-, 55- and 90 nm-high titania nanopillars, with ...
Dalby, Matthew J., McNamara, Laura E., Meek, R.M. Dominic, Seunarine, Krishna, Sjostrom, Terje, Su, Bo   +5 more
core   +2 more sources

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

Annual Review of Cell and Developmental Biology, 1996
▪ Abstract  Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
openaire   +3 more sources

Wound-induced polyploidization is dependent on Integrin-Yki signaling

Biology Open, 2021
A key step in tissue repair is to replace lost or damaged cells. This occurs via two strategies: restoring cell number through proliferation or increasing cell size through polyploidization.
Rose Besen-McNally, Kayla J. Gjelsvik, Vicki P. Losick   +2 more
doaj   +1 more source

Omics approaches to identify potential biomarkers of inflammatory diseases in the focal adhesion complex [PDF]

, 2017
Inflammatory diseases such as inflammatory bowel disease require recurrent invasive tests, including blood tests, radiology and endoscopic evaluation for diagnosis, assessment of disease activity and to determine optimal therapeutic strategies. ‘Bedside’
Ab Mutalib, Abshire, Alanko, Alastair Watson, Ambros, Bader, Barnett, Beausejour, Berger, Bouchard, Brandse, Cai, Case, Chan, Chapman, Chen, Chen, Choudhary, Chung, Dennis, Dixit, Eitel, Fuste, Geiger, Goicoechea, Goldmann, Guo, He, He, Holle, Iioka, Jahed, Johanne Brooks, Johnson, Kanehisa, Kato, Khan, Klimova, Leavitt, MacGillivray, Marquez, Maruoka, May, Mikeska, Nakano, Nakashima, Nowarski, Omran, Pardi, Perlis, Peterson, Plenge, Plevy, Ritchie, Rukmangadachar, Salim, Schiffhauer, Shi, Shibanuma, Shuto, Spalinger, Szasz, Tachibana, Tamas Korcsmaros, Thinwa, Trevino, Villani, von Mering, Wang, Wang, Weaver, Xin, Xu, Yang, You, Yu, Zaidel-Bar, Zhang, Zhang, Zhao, Zheng, Zheng   +81 more
core   +2 more sources

An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Frontiers in Cell and Developmental Biology, 2022
Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales, Qian Xue, Minna Roh-Johnson   +2 more
doaj   +1 more source

Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility

, 2014
Myxococcus xanthus is a model organism for studying bacterial social behaviors due to its ability to form complex multi-cellular structures. Knowledge of M.
Balagam, Rajesh, Czerwinski, Fabian, Igoshin, Oleg A., Kaplan, Heidi B., Litwin, Douglas B., Shaevitz, Joshua W., Sun, Mingzhai   +6 more
core   +3 more sources

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]

, 2016
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S, Auernheimer, V, Chronopoulos, A, Cortes, E, Del Rio Hernandez, AE, Fabry, B, Garcia, R, Ghassemi, S, Lachowski, D, Robinson, B, Sarper, M   +10 more
core   +1 more source

Focal adhesions are controlled by microtubules through local contractility regulation

The EMBO Journal
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia, Isabelle Arnal, Laurence Lafanechère, Boon Chuan Low, Pakorn Kanchanawong, Alex Mogilner, Alexander D Bershadsky   +9 more
doaj   +1 more source

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. [PDF]

, 1993
Integrin-mediated cell adhesion often results in cell spreading and the formation of focal adhesions. We exploited the capacity of recombinant human alpha IIb beta 3 integrin to endow heterologous cells with the ability to adhere and spread on fibrinogen
Chen, Y, Ginsberg, MH, Loftus, JC, O'Toole, TE, Takada, Y, Ylänne, J   +5 more
core  

Hydroxyapatite promotes superior adhesion and proliferation of telomerase transformed keratocytes in comparison with inert plastic skirt materials used in leading contemporary keratoprostheses [PDF]

, 2005
Aim: Published clinical series suggest the osteoodontokeratoprosthesis (OOKP) may have a lower extrusion rate than current synthetic keratoprostheses. The OOKP is anchored in the eye wall by autologous tooth.
Allen, B.D.S., Faragher, R.G.A.F., Futter, C., Hing, K.A., Mehta, J., Sandeman, S.R., Tanner, K.E.   +6 more
core   +2 more sources