Results 221 to 230 of about 83,211 (264)

Pan-cancer analysis reveals differential PERK expression across tumour types and its potential as a therapeutic target. [PDF]

Discov Oncol
Kumar S, Han N, Tsagkogeorga G, Wan MLY.
europepmc   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

IgM Hyposialylation Modulates Podocyte Vulnerability in Patients With Idiopathic Nephrotic Syndrome. [PDF]

Kidney Int Rep
Spinelli S, Gaudiano S, Garbarino A, Lugani F, La Porta E, Petretto A, Bartolucci M, Lavarello C, Grinovero N, Musante I, Scudieri P, Trivelli A, Piaggio G, Magnasco A, Degl'Innocenti ML, Granata S, Zaza G, Verrina E, Candiano G, Bruschi M.   +19 more
europepmc   +1 more source

Expression of Concern: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. [PDF]

J Am Heart Assoc
europepmc   +1 more source

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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters, 2006
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]
Taebo Sim
exaly   +3 more sources

Focal adhesion kinase in netrin-1 signaling

Nature Neuroscience, 2004
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous system. However, the signaling mechanisms that lie immediately downstream of netrin receptors remain poorly understood. Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion ...
Xiu-Rong, Ren, Guo-Li, Ming, Yi, Xie, Yan, Hong, Dong-Mei, Sun, Zhong-Qiu, Zhao, Zhu, Feng, Qiang, Wang, Sangwoo, Shim, Zhou-Feng, Chen, Hong-Jun, Song, Lin, Mei, Wen-Cheng, Xiong   +12 more
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Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase

Molecular and Cellular Biochemistry, 2005
Protein phosphatase 1delta (PP1delta) localizes to focal adhesions and associates with the focal adhesion kinase (FAK). In the present work we used deletion mutants of PP1delta and FAK to detect their reciprocally interacting domains. Dissection of PP1delta indicated 194-260 as the shortest FAK-interacting domain among those tested.
BIANCHI M, DE LUCCHINI, STEFANIA, VIETRI M, VILLA MORUZZI E.   +3 more
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Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

Biochemical and Biophysical Research Communications, 2009
Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson, Pádraig, D'Arcy, Olle, Larsson, Bita, Sehat   +3 more
openaire   +2 more sources