Results 231 to 240 of about 83,046 (264)
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Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
Biochemical and Biophysical Research Communications, 2009Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson +3 more
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Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase
Biochemical Journal, 2001Immunofluorescence studies with protein phosphatase-1 (PP1) isoforms-specific antibodies detected PP1δ, but not α or γ1, at focal adhesions. PP1δ also co-immunoprecipitated with the focal adhesion kinase (FAK) and the αv-integrin. In the present study glutathione S-transferase (GST)–PP1δ pulled-down FAK from fibroblasts extract and the interaction ...
M. FRESU +3 more
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Thrombospondin-1-Induced Migration Is Functionally Dependent Upon Focal Adhesion Kinase
Vascular and Endovascular Surgery, 2008Vascular smooth muscle cell migration is important in vascular disease. Previously, we showed thrombospondin-1 activates focal adhesion kinase in these cells. We hypothesized that focal adhesion kinase is important for thrombspondin-1-induced vascular smooth muscle cell migration. Bovine aortic smooth muscle cells were transfected with FAK397, FAK-wild
Xiu-Jie, Wang +7 more
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Cytoskeleton, 2014
Deleted in Liver Cancer‐1 (DLC1) is a RhoGTPase‐activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. Although DLC1 interacts with focal adhesion kinase (FAK), talin, and tensin, its role in focal adhesions ...
Shelly, Kaushik +3 more
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Deleted in Liver Cancer‐1 (DLC1) is a RhoGTPase‐activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. Although DLC1 interacts with focal adhesion kinase (FAK), talin, and tensin, its role in focal adhesions ...
Shelly, Kaushik +3 more
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Pathobiology, 2012
<b><i>Objective:</i></b><i>Caveolin 1</i> gene is known as a tumor promoter or suppressor, depending on the tumor type and/or tumor stage. We aimed to investigate the clinical significance of caveolin 1 protein (Cav1) expression in gastric cancer (GC).
Kyung Han, Nam +8 more
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<b><i>Objective:</i></b><i>Caveolin 1</i> gene is known as a tumor promoter or suppressor, depending on the tumor type and/or tumor stage. We aimed to investigate the clinical significance of caveolin 1 protein (Cav1) expression in gastric cancer (GC).
Kyung Han, Nam +8 more
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Cell Biology International, 2013
AbstractWe have investigated the relationship between the spreading of anchorage‐dependent cells and the surface‐density distribution of plasma membrane adhesion proteins. The surface positioning and density of integrin β1, caveolin‐1 (cav‐1), the phosphorylated caveolin‐1 (p‐cav‐1) and the focal adhesion kinase (FAK) located on the adhering cell ...
Spela Zemljič, Jokhadar +3 more
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AbstractWe have investigated the relationship between the spreading of anchorage‐dependent cells and the surface‐density distribution of plasma membrane adhesion proteins. The surface positioning and density of integrin β1, caveolin‐1 (cav‐1), the phosphorylated caveolin‐1 (p‐cav‐1) and the focal adhesion kinase (FAK) located on the adhering cell ...
Spela Zemljič, Jokhadar +3 more
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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
Bioorganic and Medicinal Chemistry Letters, 2006A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]
Taebo Sim +2 more
exaly +3 more sources
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
Schwann cells (SCs) differentiate into a myelinating cell when simultaneously adhering to an axon destined for myelination and basal lamina. We are interested in defining the signaling pathway activated by basal lamina. Using SC/sensory neuron (N) cocultures, we identified beta1 integrin and F-actin as components of a pathway leading to myelin gene ...
Chen, Li-Mei +2 more
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Schwann cells (SCs) differentiate into a myelinating cell when simultaneously adhering to an axon destined for myelination and basal lamina. We are interested in defining the signaling pathway activated by basal lamina. Using SC/sensory neuron (N) cocultures, we identified beta1 integrin and F-actin as components of a pathway leading to myelin gene ...
Chen, Li-Mei +2 more
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Experimental Cell Research, 1998
Binding of integrins to the extracellular matrix (ECM) activates various signal transduction pathways and regulates gene expression in many cell types. Integrin-dependent cytoplasmic protein/protein interactions are necessary for activation of those signal transduction cascades.
K, Danker +3 more
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Binding of integrins to the extracellular matrix (ECM) activates various signal transduction pathways and regulates gene expression in many cell types. Integrin-dependent cytoplasmic protein/protein interactions are necessary for activation of those signal transduction cascades.
K, Danker +3 more
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Biochemical and Biophysical Research Communications, 2013
Prostate cancer has become a global health concern and is one of the leading causes of cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy-3-methyl-glutarylcoenzyme-CoA (HMG-CoA) reductase inhibitor atorvastatin shows anticancer activity in prostate cancer cell lines.
Satyanarayana, Rentala +5 more
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Prostate cancer has become a global health concern and is one of the leading causes of cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy-3-methyl-glutarylcoenzyme-CoA (HMG-CoA) reductase inhibitor atorvastatin shows anticancer activity in prostate cancer cell lines.
Satyanarayana, Rentala +5 more
openaire +2 more sources