Results 251 to 260 of about 113,919,521 (303)

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma. [PDF]

Mol Carcinog
Ham E, Boedeker K, Keating CR, Ye R, Montalbano F, Mankaruse S, Ding X, Rennhack JP, Qiu W.   +8 more
europepmc   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Decoding Cytoskeletal Mechanobiology with Tunable Microenvironments. [PDF]

ACS Biomater Sci Eng
Kandel R, Chowdhury MAH, Robinson J, Reinemann DN.   +3 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance. [PDF]

J Exp Clin Cancer Res
Cordes N.
europepmc   +1 more source

Role of Focal Adhesion Kinase and NRF2 Pathways in Gastrointestinal Wound Healing. [PDF]

Int J Mol Sci
Cleveland OG, Vomhof-DeKrey EE.
europepmc   +1 more source

Beyond Integrin Activation: Kindlin-3 as an Organiser of Immune Receptor Signalling. [PDF]

Int J Mol Sci
Teng ZK, Tan SM.
europepmc   +1 more source

Decellularized Extracellular Matrix Mitigates the Senescent Phenotype and Restores Osteogenic Potential in Human Mesenchymal Stromal Cells. [PDF]

J Orthop Res
Dorais CJ, Kruger NM, Ramos-Rodriguez DH, Lee MA, Kent Leach J.   +4 more
europepmc   +1 more source