Results 271 to 280 of about 145,198 (308)

Focal adhesion kinase in netrin-1 signaling

Nature Neuroscience, 2004
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous system. However, the signaling mechanisms that lie immediately downstream of netrin receptors remain poorly understood. Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion ...
Xiu-Rong, Ren, Guo-Li, Ming, Yi, Xie, Yan, Hong, Dong-Mei, Sun, Zhong-Qiu, Zhao, Zhu, Feng, Qiang, Wang, Sangwoo, Shim, Zhou-Feng, Chen, Hong-Jun, Song, Lin, Mei, Wen-Cheng, Xiong   +12 more
openaire   +2 more sources

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

Biochemical and Biophysical Research Communications, 2009
Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson, Pádraig, D'Arcy, Olle, Larsson, Bita, Sehat   +3 more
openaire   +2 more sources

Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase

Molecular and Cellular Biochemistry, 2005
Protein phosphatase 1delta (PP1delta) localizes to focal adhesions and associates with the focal adhesion kinase (FAK). In the present work we used deletion mutants of PP1delta and FAK to detect their reciprocally interacting domains. Dissection of PP1delta indicated 194-260 as the shortest FAK-interacting domain among those tested.
BIANCHI M, DE LUCCHINI, STEFANIA, VIETRI M, VILLA MORUZZI E.   +3 more
openaire   +3 more sources

Thrombospondin-1-Induced Migration Is Functionally Dependent Upon Focal Adhesion Kinase

Vascular and Endovascular Surgery, 2008
Vascular smooth muscle cell migration is important in vascular disease. Previously, we showed thrombospondin-1 activates focal adhesion kinase in these cells. We hypothesized that focal adhesion kinase is important for thrombspondin-1-induced vascular smooth muscle cell migration.
Xiu-Jie, Wang, Kristopher, Maier, Shoichi, Fuse, Alliric I, Willis, Eric, Olson, Susan, Nesselroth, Bauer E, Sumpio, Vivian, Gahtan   +7 more
openaire   +2 more sources

Kinetic Mechanism and Rate-Limiting Steps of Focal Adhesion Kinase-1

Biochemistry, 2010
Steady-state kinetic analysis of focal adhesion kinase-1 (FAK1) was performed using radiometric measurement of phosphorylation of a synthetic peptide substrate (Ac-RRRRRRSETDDYAEIID-NH(2), FAK-tide) which corresponds to the sequence of an autophosphorylation site in FAK1. Initial velocity studies were consistent with a sequential kinetic mechanism, for
Jessica L, Schneck, Jacques, Briand, Stephanie, Chen, Ruth, Lehr, Patrick, McDevitt, Baoguang, Zhao, Angela, Smallwood, Nestor, Concha, Khyati, Oza, Robert, Kirkpatrick, Kang, Yan, James P, Villa, Thomas D, Meek, Sara H, Thrall   +13 more
openaire   +2 more sources

Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase

Biochemical Journal, 2001
Immunofluorescence studies with protein phosphatase-1 (PP1) isoforms-specific antibodies detected PP1δ, but not α or γ1, at focal adhesions. PP1δ also co-immunoprecipitated with the focal adhesion kinase (FAK) and the αv-integrin. In the present study glutathione S-transferase (GST)–PP1δ pulled-down FAK from fibroblasts extract and the interaction ...
M. FRESU, M. BIANCHI, J. T. PARSONS, VILLA, EMMA   +3 more
openaire   +3 more sources

Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer‐1 and focal adhesion kinase during early cell spreading

Cytoskeleton, 2014
Deleted in Liver Cancer‐1 (DLC1) is a RhoGTPase‐activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. Although DLC1 interacts with focal adhesion kinase (FAK), talin, and tensin, its role in focal adhesions ...
Shelly, Kaushik, Archna, Ravi, Feroz M, Hameed, Boon Chuan, Low   +3 more
openaire   +2 more sources

Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer

Pathobiology, 2012
<b><i>Objective:</i></b><i>Caveolin 1</i> gene is known as a tumor promoter or suppressor, depending on the tumor type and/or tumor stage. We aimed to investigate the clinical significance of caveolin 1 protein (Cav1) expression in gastric cancer (GC).
Kyung Han, Nam, Byung Lan, Lee, Joo Hyun, Park, Jin, Kim, Nayoung, Han, Hee Eun, Lee, Min A, Kim, Hye Seung, Lee, Woo Ho, Kim   +8 more
openaire   +2 more sources

α-Actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction

American Journal of Physiology-Cell Physiology, 2007
Physical forces including pressure, strain, and shear can be converted into intracellular signals that regulate diverse aspects of cell biology. Exposure to increased extracellular pressure stimulates colon cancer cell adhesion by a β1-integrin-dependent mechanism that requires an intact cytoskeleton and activation of focal adhesion kinase (FAK) and ...
David H, Craig, Beatrice, Haimovich, Marc D, Basson   +2 more
openaire   +2 more sources