Results 261 to 270 of about 113,919,521 (303)

Biological mechanisms underlying the effects of low-magnitude mechanical stress in osteoporosis (Review). [PDF]

Exp Ther Med
Liu Z, Han D, Wang Y, Li H, Pei X, Song Z.   +5 more
europepmc   +1 more source

Systemic Nanomechanical Single-Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation. [PDF]

Adv Sci (Weinh)
Ku M, Kwon J, Yoon N, Byeon HK, Yang J.
europepmc   +1 more source

Design and Synthesis of 7H-Pyrrolo[2,3-d]Pyrimidines as Focal Adhesion Kinase Inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters, 2006
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]
Taebo Sim, Donald Karanewsky, Xiang-Ju Gu   +2 more
exaly   +4 more sources

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Focal adhesion kinase in netrin-1 signaling

Nature Neuroscience, 2004
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous system. However, the signaling mechanisms that lie immediately downstream of netrin receptors remain poorly understood. Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion ...
Xiu-Rong, Ren, Guo-Li, Ming, Yi, Xie, Yan, Hong, Dong-Mei, Sun, Zhong-Qiu, Zhao, Zhu, Feng, Qiang, Wang, Sangwoo, Shim, Zhou-Feng, Chen, Hong-Jun, Song, Lin, Mei, Wen-Cheng, Xiong   +12 more
openaire   +2 more sources

Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase

Molecular and Cellular Biochemistry, 2005
Protein phosphatase 1delta (PP1delta) localizes to focal adhesions and associates with the focal adhesion kinase (FAK). In the present work we used deletion mutants of PP1delta and FAK to detect their reciprocally interacting domains. Dissection of PP1delta indicated 194-260 as the shortest FAK-interacting domain among those tested.
BIANCHI M, DE LUCCHINI, STEFANIA, VIETRI M, VILLA MORUZZI E.   +3 more
openaire   +3 more sources

Kinetic Mechanism and Rate-Limiting Steps of Focal Adhesion Kinase-1

Biochemistry, 2010
Steady-state kinetic analysis of focal adhesion kinase-1 (FAK1) was performed using radiometric measurement of phosphorylation of a synthetic peptide substrate (Ac-RRRRRRSETDDYAEIID-NH(2), FAK-tide) which corresponds to the sequence of an autophosphorylation site in FAK1. Initial velocity studies were consistent with a sequential kinetic mechanism, for
Jessica L, Schneck, Jacques, Briand, Stephanie, Chen, Ruth, Lehr, Patrick, McDevitt, Baoguang, Zhao, Angela, Smallwood, Nestor, Concha, Khyati, Oza, Robert, Kirkpatrick, Kang, Yan, James P, Villa, Thomas D, Meek, Sara H, Thrall   +13 more
openaire   +2 more sources

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

Biochemical and Biophysical Research Communications, 2009
Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson, Pádraig, D'Arcy, Olle, Larsson, Bita, Sehat   +3 more
openaire   +2 more sources