Results 281 to 290 of about 113,919,521 (303)

Requirement of Caveolae Microdomains in Extracellular Signal‐Regulated Kinase and Focal Adhesion Kinase Activation Induced by Endothelin‐1 in Primary Astrocytes

Journal of Neurochemistry, 1999
Abstract : Endothelin‐1 (ET‐1) mitogenic activity in astrocytes is mediated by the activation of the extracellular signal‐regulated kinase (ERK) pathway together with the Rho‐dependent activation of the focal adhesion kinase (FAK) pathway. To clarify the mechanisms responsible for the coordinate activation of both pathways in the ET‐1 signal ...
A, Teixeira, N, Chaverot, C, Schröder, A D, Strosberg, P O, Couraud, S, Cazaubon   +5 more
openaire   +2 more sources

Adenoviral Gene Transfer of Endothelin-1 in the Lung Induces Pulmonary Fibrosis through the Activation of Focal Adhesion Kinase

American Journal of Respiratory Cell and Molecular Biology, 2012
Abstract Endothelin-1 (ET-1) has been implicated in the development of pulmonary fibrosis, based on its capacity in vitro to promote extracellular matrix (ECM) production and contraction, and on studies showing elevated expression of ET-1 and its receptors in patients with pulmonary fibrosis.
Lagares, David, Busnadiego, Óscar, García-Fernández, Rosa Ana,, Lamas Peláez, Santiago, Rodríguez-Pascual, Fernando   +4 more
openaire   +3 more sources

[Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013
To analyze the expression of deleted in liver cancer 1 (DLC1) and phosphorelated focal adhesion kinase (p-FAK) in breast cancer tissue to further understand the molecular mechanisms of the carcinogenesis and metastasis of breast cancer.Immunohistochemistry was employed to determine the protein level of DLC1 and p-FAK in 61 breast cancer, 30 benign ...
Yun, Feng, Hui-xing, Zhou, Jun-hong, Li, Zhen-yu, Li, Wei-gang, Cheng, Meng-lin, Jin, Liang, He   +6 more
openaire   +1 more source

Faculty Opinions recommendation of Focal adhesion kinase in netrin-1 signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2004
openaire   +2 more sources

Endothelin-1 Induction Of Focal Adhesion Kinase In Normal Human Lung Fibroblasts Is Dependent On Rho-kinase

B66. FIBROBLAST MATRIX, CYTOSKELETON, AND MIGRATION, 2010
Priya Kulasekaran, Victor J. Thannickal, Jeffrey C. Horowitz   +2 more
openaire   +1 more source

Structural Basis of Focal Adhesion Kinase Activation on Lipid Membranes

EMBO Journal, 2020
Oscar Llorca, Margaret Frame, Jasminka Boskovic   +2 more
exaly  

Focal Adhesion Kinase: In Command and Control of Cell Motility

Nature Reviews Molecular Cell Biology, 2005
David Schlaepfer
exaly  

A Phase I, Pharmacokinetic and Pharmacodynamic Study of GSK2256098, a Focal Adhesion Kinase Inhibitor, in Patients With Advanced Solid Tumors

Annals of Oncology, 2016
Antoine Hollebecque, J C Soria, H K Gan
exaly  

Focal Adhesion Kinase and Associated Proteins

Current Opinion in Cell Biology, 1994
J T Parsons, J Thomas Parsons, M D Schaller   +2 more
exaly  

Expression of Focal Adhesion Kinase Gene and Invasive Cancer

Lancet, The, 1993
W G Cance, E T Liu
exaly