Results 281 to 290 of about 145,198 (308)
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Biochemical and Biophysical Research Communications, 2013
Prostate cancer has become a global health concern and is one of the leading causes of cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy-3-methyl-glutarylcoenzyme-CoA (HMG-CoA) reductase inhibitor atorvastatin shows anticancer activity in prostate cancer cell lines.
Satyanarayana, Rentala +5 more
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Prostate cancer has become a global health concern and is one of the leading causes of cancer death of men after lung and gastric cancers. It has been suggested that the 3-hydroxy-3-methyl-glutarylcoenzyme-CoA (HMG-CoA) reductase inhibitor atorvastatin shows anticancer activity in prostate cancer cell lines.
Satyanarayana, Rentala +5 more
openaire +2 more sources
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
Bioorganic & Medicinal Chemistry Letters, 2006A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]
Ha-Soon, Choi +14 more
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007
Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better differentiated phenotype by regulating cell motility in the context of remodeling and retarding tumor cell metastasis by enhancing cell-matrix attachment.
Lauren, Taglia +3 more
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Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better differentiated phenotype by regulating cell motility in the context of remodeling and retarding tumor cell metastasis by enhancing cell-matrix attachment.
Lauren, Taglia +3 more
openaire +2 more sources
Experimental Cell Research, 1998
Binding of integrins to the extracellular matrix (ECM) activates various signal transduction pathways and regulates gene expression in many cell types. Integrin-dependent cytoplasmic protein/protein interactions are necessary for activation of those signal transduction cascades.
K, Danker +3 more
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Binding of integrins to the extracellular matrix (ECM) activates various signal transduction pathways and regulates gene expression in many cell types. Integrin-dependent cytoplasmic protein/protein interactions are necessary for activation of those signal transduction cascades.
K, Danker +3 more
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The American Journal of Surgery, 2006
Pressure stimulates colon cancer adhesion via focal adhesion kinase (FAK). Extracellular pressures reaching 29 mm Hg have been reported in rapidly growing breast cancers, and tumors experience pressure during surgical manipulation. We hypothesized that pressure stimulates breast cancer adhesion and that CARP-1, which influences cancer biology, inhibits
Christina, Downey +6 more
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Pressure stimulates colon cancer adhesion via focal adhesion kinase (FAK). Extracellular pressures reaching 29 mm Hg have been reported in rapidly growing breast cancers, and tumors experience pressure during surgical manipulation. We hypothesized that pressure stimulates breast cancer adhesion and that CARP-1, which influences cancer biology, inhibits
Christina, Downey +6 more
openaire +2 more sources
Faculty Opinions recommendation of Focal adhesion kinase in netrin-1 signaling.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2004openaire +2 more sources
Targeting FAK in anticancer combination therapies
Nature Reviews Cancer, 2021John C Dawson +2 more
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Focal adhesion kinase: in command and control of cell motility
Nature Reviews Molecular Cell Biology, 2005David D Schlaepfer
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The role of focal-adhesion kinase in cancer — a new therapeutic opportunity
Nature Reviews Cancer, 2005Neil O Carragher, Valerie G Brunton
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Structural Basis for the Autoinhibition of Focal Adhesion Kinase
Cell, 2007Daniel Lietha +2 more
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