Results 11 to 20 of about 82,988 (278)
Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions. [PDF]
PLoS ONE, 2016 Integrin adhesome proteins bind each other in alternative manners, forming within the cell diverse cell-matrix adhesion sites with distinct properties. An intriguing question is how such modular assembly of adhesion sites is achieved correctly solely by ...
Jana Harizanova +6 more
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Paxillin: A Hub for Mechano-Transduction from the β3 Integrin-Talin-Kindlin Axis
Frontiers in Cell and Developmental Biology, 2022 Focal adhesions are specialized integrin-dependent adhesion complexes, which ensure cell anchoring to the extracellular matrix. Focal adhesions also function as mechano-signaling platforms by perceiving and integrating diverse physical and (bio)chemical ...
Marta Ripamonti +2 more
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Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption. [PDF]
PLoS ONE, 2015 Focal adhesions are integrin-based structures that link the actin cytoskeleton and the extracellular matrix. They play an important role in various cellular functions such as cell signaling, cell motility and cell shape.
Ermin Hadzic +10 more
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Focal adhesions in osteoneogenesis [PDF]
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010 As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material ...
M J P, Biggs, M J, Dalby
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α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
PLoS ONE, 2015 α-Actinins (ACTNs) are known to crosslink actin filaments at focal adhesions in migrating cells. Among the four isoforms of mammalian ACTNs, ACTN1 and ACTN4 are ubiquitously expressed.
Miki Fukumoto +3 more
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Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions [PDF]
Journal of Biological Chemistry, 2004 Focal adhesion kinase (FAK) activity and Ca(2+) signaling led to a turnover of focal adhesions (FAs) required for cell spreading and migration. We used yellow Cameleon-2 (Ycam), a fluorescent protein-based Ca(2+) sensor fused to FAK or to a FAK-related non-kinase domain, to measure simultaneously local Ca(2+) variations at FA sites and FA dynamics ...
Grégory, Giannone +6 more
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Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells
Cell Death and Disease, 2023 Cell invasion is a highly complex process that requires the coordination of cell migration and degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer cell types these processes are driven by the regulated formation ...
Marlène Legrand +9 more
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Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.
PLoS ONE, 2017 Focal adhesions are often observed at the cell's periphery. We provide an explanation for this observation using a system-level mathematical model of a cell interacting with a two-dimensional substrate.
Magdalena A Stolarska +1 more
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Hax1 regulate focal adhesion dynamics through IQGAP1
Cell Communication and Signaling, 2023 Cell migration is a highly orchestrated process requiring the coordination between the cytoskeleton, cell membrane and extracellular matrix adhesions. Our previous study demonstrated that Hax1 interacts with EB2, a microtubule end-binding protein, and ...
Xinyi Ren +5 more
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Circulation Research, 2006 The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a ...
Lewis H, Romer +2 more
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