Frontiers in Cell and Developmental Biology, 2022 Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales +2 more
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Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions [PDF]
, 2016 Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy.
Dedecker, Peter +10 more
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TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly [PDF]
Journal of Cell Science, 2014 Focal adhesions (FAs) are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of FAs is critical for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating FA dynamics.
Pradeep D, Uchil +13 more
openaire +3 more sources
A kinetic model for RNA-interference of focal adhesions [PDF]
, 2013 Background: Focal adhesions are integrin-based cell-matrix contacts that transduce and integrate mechanical and biochemical cues from the environment. They develop from smaller and more numerous focal complexes under the influence of mechanical force and
Hoffmann, Max, Schwarz, Ulrich Sebastian
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Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces. [PDF]
, 2015 Although adhesive interactions between cells and nanostructured interfaces have been studied extensively, there is a paucity of data on how nanostructured interfaces repel cells by directing cell migration and cell-colony organization.
Grigoropoulos, Costas P. +5 more
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Two-photon imaging of cancer cell extravasation in live mice [PDF]
, 2011 MDA-MB-231 breast cancer cells were engineered to express cytoplasmic paxillin-GFP and nuclear H2B-mCherry. In order to image extravasation, the cancer cells were injected in the blood stream of nude mice.
Aguilar, Jose S +4 more
core +1 more source
Focal adhesion kinase‐dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions [PDF]
Biology of the Cell, 2010 Background information. FAK (focal adhesion kinase), an essential non‐receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signalling and mechanotransduction. FAK‐dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion.
David W, Dumbauld +3 more
openaire +2 more sources
PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
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Actin cap associated focal adhesions and their distinct role in cellular mechanosensing [PDF]
, 2012 The ability for cells to sense and adapt to different physical microenvironments plays a critical role in development, immune responses, and cancer metastasis.
Feng, Yunfeng +6 more
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The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
eLife, 2016 Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
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