Functions of nonmuscle myosin II in assembly of the cellular contractile system. [PDF]
PLoS ONE, 2012 The contractile system of nonmuscle cells consists of interconnected actomyosin networks and bundles anchored to focal adhesions. The initiation of the contractile system assembly is poorly understood structurally and mechanistically, whereas system's ...
Maria Shutova +3 more
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The mechano-chemistry of cytoskeletal force generation [PDF]
, 2014 In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as ...
Garikipati, Krishna, Maraldi, Mirko
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Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress [PDF]
, 2018 Mechanical stimuli play a key role in many cell functions such as proliferation, differentiation and migration. In the mammary gland, mechanical signals such as the distension of mammary epithelial cells due to udder filling are proposed to be directly ...
Bianchi, Micaela +5 more
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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
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In vivo epidermal migration requires focal adhesion targeting of ACF7
Nature Communications, 2016 The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal
Jiping Yue +11 more
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Vinculin expression in MC3T3-E1 cells in response to mechanical stimulus
Data in Brief, 2016 Loading frequency is known to influence the expression of the focal adhesions of the adherent cells. A small cyclical tensile force was transmitted to mouse pre-osteoblast MC3T3-E1 cells through PDMS substrates of varying stiffness.
J.J. Cora-Cruz +2 more
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A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration [PDF]
, 2014 Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Asuri, Prashanth +2 more
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PLoS ONE, 2012 A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied
Bin Chen +4 more
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Investigation of the limits of nanoscale filopodial interactions [PDF]
, 2014 Mesenchymal stem cells are sensitive to changes in feature height, order and spacing. We had previously noted that there was an inverse relationship between osteoinductive potential and feature height on 15-, 55- and 90 nm-high titania nanopillars, with ...
Dalby, Matthew J. +5 more
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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract  Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
openaire +3 more sources