Results 51 to 60 of about 82,988 (278)

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Development of Novel Flow Chamber to Study Endothelial Cell Morphology: Effects of Shear Flow with Uniform Spatial Gradient on Distribution of Focal Adhesion

Journal of Biomechanical Science and Engineering, 2013
Fluid shear stress (SS) is well known to cause morphological changes in vascular endothelial cells (ECs) accompanied by alteration in actin cytoskeletal structure and distribution of focal adhesions.
Daisuke YOSHINO, Naoya SAKAMOTO, Keita TAKAHASHI, Eri INOUE, Masaaki SATO   +4 more
doaj   +1 more source

High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. [PDF]

PLoS ONE, 2011
Focal adhesions (FAs) are macromolecular complexes that provide a linkage between the cell and its external environment. In a motile cell, focal adhesions change size and position to govern cell migration, through the dynamic processes of assembly and ...
Mathew E Berginski, Eric A Vitriol, Klaus M Hahn, Shawn M Gomez   +3 more
doaj   +1 more source

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Electrical Stimulation Causes Activation of c-Src and Focal Adhesion Kinase in Fibroblasts

Biology and Life Sciences Forum, 2023
Stimulation of the skin and muscles in the field of acupuncture and moxibustion has been shown to increase local blood flow and metabolism or maintain the body in a sustained healthy state.
Kazuo Katoh
doaj   +1 more source

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
A Banno, A Carisey, A Del Rio, A Kishino, AD Bershadsky, AR Gingras, BD Hoffman, BT Goult, BT Goult, C Ciobanasu, C Grashoff, E Goksoy, F Margadant, GCK Roberts, H Chen, H Chen, H Chen, H Fu, H Hirata, H-S Lee, H-S Lee, J Han, JD Humphries, NJ Anthis, PR Elliott, PRJ Bois, PRJ Bois, SE Lee, SJ Ellis, T Wieprecht, TJ Proszynski, V Vogel, Y Gao, Y Sawada, Y Sawada   +34 more
core   +2 more sources

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Distribution of Cytoskeletal Components in Endothelial Cells in the Guinea Pig Renal Artery

International Journal of Cell Biology, 2012
The cytoskeletal components of endothelial cells in the renal artery were examined by analysis of en face preparations under confocal laser scanning microscopy. Renal arterial endothelial cells were shown to be elongated along the direction of blood flow,
Kazuo Katoh, Yasuko Noda
doaj   +1 more source

Anti-correlation of HER2 and focal adhesion complexes in the plasma membrane.

PLoS ONE, 2020
Excess presence of the human epidermal growth factor receptor 2 (HER2) as well as of the focal adhesion protein complexes are associated with increased proliferation, migratory, and invasive behavior of cancer cells.
Florian Weinberg, Mitchell Kim Liong Han, Indra Navina Dahmke, Aránzazu Del Campo, Niels de Jonge   +4 more
doaj   +1 more source