Results 231 to 240 of about 457,931 (292)

Increased synthesis of folate transporters regulates folate transport in conditions of ethanol exposure and folate deficiency

Molecular and Cellular Biochemistry, 2015
Excessive alcohol consumption and dietary folate inadequacy are the main contributors leading to folate deficiency (FD). The present study was planned to study regulation of folate transport in conditions of FD and ethanol exposure in human embryonic kidney cell line.
Shilpa Thakur, Deepti More, Beenish Rahat, K. L. Khanduja, J. Kaur   +4 more
semanticscholar   +3 more sources

Rodent Intestinal Folate Transporters (SLC46A1): Secondary Structure, Functional Properties, and Response to Dietary Folate Restriction

American Journal of Physiology - Cell Physiology, 2007
Myles H. Akabas, Eugenia Tsai, Michaela Jansen   +2 more
exaly   +2 more sources

Abstract 4903: Levels of folate transporters impact the compartmentalization of one-carbon metabolism in the mitochondria vs cytosol providing a unique vulnerability to SHMT inhibition

Cancer Research, 2023
These studies characterize the critical role of the Reduced Folate Carrier (RFC) and the Proton Coupled Folate Transporter (PCFT) as determinants of cancer cell reliance on mitochondrial vs cytosolic one carbon (C1) metabolism, to identify a unique ...
M. Schneider, C. O'Connor, X. Bao, Md Junayed Nayeen, Z. Hou, Jing Li, A. Gangjee, L. Matherly   +7 more
semanticscholar   +1 more source

The folate-linked chitosan-coated Kaempferol/HSA nano-transporters (FCKH-NTs) as the selective apoptotic inducer in human MCF-7 breast cancer cell line

Drug Development and Industrial Pharmacy, 2023
Background Kaempferol, the natural bioactive flavonoid, has been utilized as an efficient anti-breast cancer compound. In the current study, the Kaempferol’s cellular uptake and its aqueous solubility were improved by using human serum albumin (HSA) as ...
Mahshad Mollaei, Masoud Homayouni Tabrizi, Ali Es-haghi   +2 more
semanticscholar   +1 more source

Stage specific gene expression of folate mediated one-carbon metabolism enzymes and transporters in buffalo oocytes and pre-implantation embryos.

Gene Expression Patterns, 2022
DNA synthesis and methylations are crucial during pre-implantation embryonic development, and are mediated by one-carbon metabolism of folates. Folates, transported into the cells via folate receptors (FOLR1 and FOLR2) and carriers (SLC19A1), are ...
S. Ansari, S. Saini, Shradha Jamwal, A. Thakur, Amit Kumar, Priya Sehrawat, P. Devi, D. Malakar   +7 more
semanticscholar   +1 more source

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption [PDF]

Cell, 2006
Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic processes. While folates are absorbed in the acidic milieu of the upper small intestine, the underlying absorption mechanism has not been defined. We now report the identification of a human proton-coupled, high-affinity folate transporter that recapitulates ...
Myles H. Akabas, Eugenia Tsai, Michaela Jansen   +2 more
exaly   +3 more sources