Results 251 to 260 of about 457,931 (292)
Journal of Biological Chemistry, 2011 Tetrahydrofolates are essential cofactors for DNA synthesis and methionine metabolism. Malaria parasites are capable both of synthesizing tetrahydrofolates and precursors de novo and of salvaging them from the environment. The biosynthetic route has been studied in some detail over decades, whereas the molecular mechanisms that underpin the salvage ...
Giancarlo Biagini +2 more
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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1986
Although a matter of some controversy in the face of differing experimental systems employing a wide range of substrate concentrations and conditions, there is a growing consensus that monoglutamyl folates are taken up by the intestinal epithelial cell by a structure-specific and energy-mediated transport process coded-for genetically.
I H, Rosenberg, J, Zimmerman, J, Selhub
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Although a matter of some controversy in the face of differing experimental systems employing a wide range of substrate concentrations and conditions, there is a growing consensus that monoglutamyl folates are taken up by the intestinal epithelial cell by a structure-specific and energy-mediated transport process coded-for genetically.
I H, Rosenberg, J, Zimmerman, J, Selhub
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Gastroenterology, 2009
G A A b st ra ct s HIF-1α signaling in response to Cdif toxin. Results: Caco-2 cells exposed to Cdif toxin displayed a significant increase in HIF-1α transcription, protein levels and DNA binding. Cdif toxin-induced HIF-1α protein accumulation was attenuated by nitric oxide synthase inhibitors.
Nissar Ahmad Wani, Jyotdeep Kaur
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G A A b st ra ct s HIF-1α signaling in response to Cdif toxin. Results: Caco-2 cells exposed to Cdif toxin displayed a significant increase in HIF-1α transcription, protein levels and DNA binding. Cdif toxin-induced HIF-1α protein accumulation was attenuated by nitric oxide synthase inhibitors.
Nissar Ahmad Wani, Jyotdeep Kaur
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The Mechanism of Mitochondrial Folate Transport by the Mitochondrial Folate Transporter
2010VCU Theses and ...
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Therapeutic Strategies Targeting Proteins That Regulate Folate and Reduced Folate Transport
Journal of Chemotherapy, 1999Folate is an essential vitamin which acts as a precursor for cofactors that regulate a variety of biochemical reactions. Cellular uptake of endogenous folates as well as antifolate agents such as methotrexate may be regulated by two independent transport proteins, the folate receptor and the reduced folate carrier.
T M, Trippett, J R, Bertino
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The Journal of Nutritional Biochemistry, 2015
Folic acid is an essential micronutrient, deficiency of which can lead to disturbance in various metabolic processes of cell. Folate transport across intestine occurs via the involvement of specialized folate transporters viz. proton coupled folate transporter (PCFT) and reduced folate carrier (RFC), which express at the membrane surfaces.
Shilpa, Thakur +4 more
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Folic acid is an essential micronutrient, deficiency of which can lead to disturbance in various metabolic processes of cell. Folate transport across intestine occurs via the involvement of specialized folate transporters viz. proton coupled folate transporter (PCFT) and reduced folate carrier (RFC), which express at the membrane surfaces.
Shilpa, Thakur +4 more
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Regulation of Reduced-Folate Transporter-1 in Retinal Pigment Epithelial Cells by Folate
Current Eye Research, 2005Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. RFT-1 is localized to the RPE apical membrane and transports folate from RPE to photoreceptor cells.
Vadivel Ganapathy +2 more
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Effect of human milk folate binding protein on folate intestinal transport
Archives of Biochemistry and Biophysics, 1986The present study examined the effect of human milk folate binding protein (FBP) on the intestinal transport of 5-methyltetrahydrofolate (5-CH3H4PteGlu). This was performed by examining the transport of radiolabeled 5-CH3H4PteGlu bound to FBP using everted sacs of rat intestine.
H M, Said, D W, Horne, C, Wagner
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Folate and anti-folate transport in mammalian cells.
Antibiotics and chemotherapy, 1980The transport of folate by murine leukemia cells, hepatic cells, choroid plexus and intestine is a complicated process involving at least two different carrier-mediated processes and/or passive diffusion by certain cells. Although there are marked similarities between many of the models studied, there are also striking differences, especially with ...
B A, Kamen, J R, Bertino
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The folate and thiamine transport proteins of lactobacillus casei
Journal of Supramolecular Structure, 1977AbstractTwo separate binding proteins, one specific for folate and the other for thiamine, have been isolated from membrane fragments of Lactobacillus casei. Purification to homogeneity was achieved by fractionation of the Triton‐solubilized proteins with microgranular silica (Quso G‐32) and Sephadex G‐150. Amino acid analyses revealed that the folate (
G B, Henderson +3 more
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