Results 261 to 270 of about 457,931 (292)

Molecular Cloning of the Human Placental Folate Transporter

Biochemical and Biophysical Research Communications, 1995
We have isolated a cDNA clone from a human placental library which codes for a functional folate transporter (hFOLT). An RT-PCR product obtained from mouse intestinal mRNA using primers specific for the mouse folate transporter cDNA was used to screen the cDNA library.
P D, Prasad, S, Ramamoorthy, F H, Leibach, V, Ganapathy   +3 more
openaire   +2 more sources

An exploration into the transplacental transfer of microplastics through placental transporters.

Journal of Environmental Science
Microplastic (MP) and nanoplastic (NP) exposure has been proven to cause placental damage and fetal dysplasia in mammals. The distribution and accumulation of MPs and NPs in human placental tissue were partly explored.
Binbin Guo, Yawei Wang, Weilin Wang, R. Guan, Dong-Quan Li, Qiyue Wang, Chunyan Zhao   +6 more
semanticscholar   +1 more source

Disorders of Folate Metabolism and Transport

2013
Folates play an essential role in one-carbon methyl transfer reactions, mediating several biological processes including DNA synthesis, regulation of gene expression through methylation reactions, embryonic central nervous system development, synthesis and breakdown of amino acids, and synthesis of thymidines, purines, and neurotransmitters. In mammals,
Scaglia, F, Blau, N
openaire   +2 more sources

Folate disorder in the atdfb mutant triggers a compensatory nitrogen starvation response by altering nitrate transport and assimilation.

Biochemical and Biophysical Research Communications - BBRC
Folates are essential cofactors that bridge carbon and nitrogen metabolism. However, the role of specific folate derivatives in regulating nitrogen homeostasis remains poorly understood.
Hong-Yan Meng, Bayan Huang, Xing-Juan Li, Wen-Hua Wang, Ming-Qiong Zheng, En-Ming He   +5 more
semanticscholar   +1 more source

Computational insights into maternal environmental pollutants and folate pathway regulation.

Reproductive Toxicology
Exposure to environmental pollutants during pregnancy can adversely affect fetal growth and postnatal development. While numerous studies have explored the interaction between environmental toxic chemicals and the folate pathway, few have examined their ...
A. Shukla, S. Ahamad, Prachi Kukshal
semanticscholar   +1 more source

Folate-mediated Transport of Nanoparticles across the Placenta

Pharmaceutical Nanotechnology
Background: In this study, a prototype of a targeted nanocarrier for drug delivery for prenatal therapy of the developing fetus was developed and examined in vitro and ex vivo. The folate transport mechanism in the human placenta was utilized as a possible pathway for the transplacental delivery of targeted ...
Irina, Kalashnikova, Svetlana, Patrikeeva, Tatiana N, Nanovskaya, Yaroslav A, Andreev, Mahmoud S, Ahmed, Erik, Rytting   +5 more
openaire   +2 more sources

Methotrexate influx via folate transporters into alveolar epithelial cell line A549.

Drug Metabolism and Pharmacokinetics, 2015
M. Kawami, Mioka Miyamoto, R. Yumoto, M. Takano   +3 more
semanticscholar   +1 more source

Impact of Folate Bio-Enriched Fermented Beverage on Vitamin D Receptor and Folate Transporters Expression in the Colon: Insights from In Vitro and In Vivo Studies

Food Bioscience
A. C. C. Cucick, J. Laiño, A. de Moreno de Leblanc, M. E. Herkenhoff, J. Y. Suzuki, Bernadette Dora Gombossy Melo Franco, J. P. Fabi, J. G. Leblanc, Susana Marta Isay Saad   +8 more
semanticscholar   +1 more source

Folates transport in placentas

2020
Erika Castaño-Moreno, Raúl Piñuñuri, Reyna Peñailillo, Paola Casanello, Miguel Llanos, Ana María Ronco   +5 more
openaire   +1 more source

Regulation at multiple levels control the expression of folate transporters in liver cells in conditions of ethanol exposure and folate deficiency.

Biofactors, 2015
Shilpa Thakur, J. Kaur
semanticscholar   +1 more source