Results 181 to 190 of about 14,832,680 (288)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Follicular helper T cells in autoimmune diseases [PDF]

Rheumatology, 2014
Gábor, Papp, Krisztina, Szabó, Zoltán, Szekanecz, Margit, Zeher   +3 more
openaire   +2 more sources

Immunological dysregulation of follicular helper T cells, follicular regulatory T cells, and follicular cytotoxic T cells is associated with disease activity and identifies exploratory immune patterns in rheumatoid arthritis. [PDF]

Front Immunol
Fan Y, Li B, Wu R, Liu X, Zi X, Xie Y, Gao C, Wang C.   +7 more
europepmc   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source

Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics. [PDF]

Front Immunol
Shen C, Fu Q.
europepmc   +1 more source

CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. [PDF]

Nat Commun, 2022
Baiyegunhi OO, Mann J, Khaba T, Nkosi T, Mbatha A, Ogunshola F, Chasara C, Ismail N, Ngubane T, Jajbhay I, Pansegrouw J, Dong KL, Walker BD, Ndung'u T, Ndhlovu ZM.   +14 more
europepmc   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Editorial: CD4 T Follicular Helper Cells in HIV

Frontiers in Immunology, 2017
Smita S. Iyer
doaj   +1 more source

Follicular Helper T Cells and B Cell Maturation in Patients with 22q11.2 Deletion Syndrome and Recurrent Infections. [PDF]

J Clin Immunol
Alsaati N, Beigel K, Maurer K, Henrickson SE, Knight M, Green A, Giunta V, McGinn DE, Wang B, Crowley TB, McDonald-McGinn DM, Sullivan KE.   +11 more
europepmc   +1 more source

Abnormal Function of Circulating Follicular Helper T Cells Leads to Different Manifestations of B Cell Maturation and Differentiation in Patients with Osteosarcoma. [PDF]

J Healthc Eng, 2022
Zhao G, Liang J, Cao J, Jiang S, Lu J, Jiang B.   +5 more
europepmc   +1 more source