Results 261 to 270 of about 253,632 (296)

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Nature Reviews Rheumatology, 2019
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity
Jun Deng, Válter R Fonseca, Luis Graca
exaly   +4 more sources

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis.

Journal of Allergy and Clinical Immunology, 2019
BACKGROUND The function of follicular regulatory T (TFR) cells, especially in regulating IgE production in patients with allergic diseases, is poorly understood.
Yin Yao, Zhi-chao Wang, Nan Wang, Pengcheng Zhou, Cai-Ling Chen, Jia Song, L. Pan, B. Liao, Xin-hao Zhang, Yongshi Yang, Xiao-yan Xu, R. Zhu, Di Yu, Zheng Liu   +13 more
semanticscholar   +3 more sources

Effects of allergen immunotherapy on follicular regulatory T cells

Current Opinion in Allergy & Clinical Immunology, 2023
Purpose of review Emerging evidence indicating that the dysfunction of T follicular regulatory (TFR) cells contributes to excessive immunoglobulin E (IgE) production and the development of allergic diseases.
Shi-Ran Sun, Yin Yao, Z. Liu
semanticscholar   +3 more sources

Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren's syndrome

Journal of Leukocyte Biology, 2020
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease, characterized by lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic damage.
Weiqian Chen, Fan Yang, Guanhua Xu, Ji-lin Ma, Jin Lin   +4 more
semanticscholar   +3 more sources

Follicular Helper T Cells and Follicular Regulatory T Cells Involved in Immune Disorders of Idiopathic Membranous Nephropathy

Indian Journal of Pediatrics, 2023
To investigate the role of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in immune disorders of idiopathic membranous nephropathy (IMN).Peripheral blood samples of 41 IMN patients and 30 healthy controls were collected.
Lin Xu, Dilreba Tayier, Shufen Yang, Xueqin Zhang, Chen Lu   +4 more
semanticscholar   +3 more sources

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.

Immunity, 2017
Lifan Xu, Qizhao Huang, Haoqiang Wang, Yaxing Hao, Qiang Bai, Jianjun Hu, Yiding Li, Pengcheng Wang, Xiangyu Chen, Ran He, Bingshou Li, Xia Yang, Tingting Zhao, Yanyan Zhang, Yifei Wang, Juanjuan Ou, Houjie Liang, Yuzhang Wu, Xinyuan Zhou, L. Ye   +19 more
semanticscholar   +3 more sources

Developmental bifurcation of human T follicular regulatory cells

Science Immunology, 2021
Transcriptomics supports that human T reg cells differentiate into mature lymphoid tissue or circulating T follicular regulatory cells.
Saumya Kumar, Válter R. Fonseca, Filipa Ribeiro, Afonso P. Basto, Ana Água-Doce, Marta Monteiro, Dikélélé Elessa, Ricardo J. Miragaia, Tomás Gomes, Eliane Piaggio, Elodie Segura, Margarida Gama-Carvalho, Sarah A. Teichmann, Luis Graca   +13 more
openaire   +2 more sources

The expanding family of T follicular regulatory cells

Science Immunology, 2023
The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses in providing optimal antibody production and preventing events leading to autoimmunity (see the related Research Article by Le Coz et al .).
Luis Graca, Johanne Jacobsen, Saumya Kumar   +2 more
openaire   +2 more sources

Current Advances in Follicular Regulatory T-Cell Biology

Critical Reviews in Immunology, 2022
Follicular regulatory T (T_FR) cells are a population of CD4⁺ T-cells that concomitantly express markers for regulatory T-cells and follicular helper T (T_FH) cells, and have been predominantly implicated in the regulation of humoral immunity via their suppressive functions.
Sadashib, Ghosh, Jianmei W, Leavenworth
openaire   +2 more sources

SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation

Science, 2020
SOSTDC1 for germinal center regulation T follicular helper (T FH ) cells are CD4 + T cells that facilitate B cell antibody production and B cell memory responses in the germinal centers (GCs) of lymphoid organs. These activities are in turn restrained by T follicular regulatory (T
Xin Wu, Yun Wang, Rui Huang, Qujing Gai, Haofei Liu, Meimei Shi, Xiang Zhang, Yonglin Zuo, Longjuan Chen, Qiwen Zhao, Yu Shi, Fengchao Wang, Xiaowei Yan, Huiping Lu, Senlin Xu, Xiaohong Yao, Lin Chen, Xia Zhang, Qiang Tian, Ziyan Yang, Bo Zhong, Chen Dong, Yan Wang, Xiu-Wu Bian, Xindong Liu   +24 more
openaire   +2 more sources