Results 271 to 280 of about 253,632 (296)

T follicular regulatory cells

Immunological Reviews, 2016
SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Peter T, Sage, Arlene H, Sharpe
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The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Acta Haematologica, 2023
Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods: The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups
Mingling, Sun, Xiujuan, Wang, Lei, Wang, Xinyou, Wang, Wenxia, Fan, Ying, Liu, Qinzhi, Li, Ning, Zhang, Xinhong, Guo   +8 more
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Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome

2021
With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu, Meiling, Wu, Yun, Feng, Jiangang, Shen, Liwei, Lu, Xiang, Lin   +5 more
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Advances in T follicular helper and T follicular regulatory cells in transplantation immunity

Transplantation Reviews, 2018
B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance ...
Maogen Chen, Xiaohong Lin, null Cheukfai Li, Nancy Olsen, Xiaoshun He, Song Guo Zheng   +5 more
openaire   +2 more sources

T follicular helper and T follicular regulatory cells in colorectal cancer: A complex interplay

Journal of Immunological Methods, 2020
Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (TFH) and T follicular regulatory (TFR) cells are specialized providers of T-cells to help B-cells and shaping germinal centers (GC) response.
Helal F, Hetta, Azza, Elkady, Ramadan, Yahia, Ahmed Kh, Meshall, Mahmoud M, Saad, Mohamed A, Mekky, Israa M S, Al-Kadmy   +6 more
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Nonbinary Roles for T Follicular Helper Cells and T Follicular Regulatory Cells in the Germinal Center Response

The Journal of Immunology, 2023
Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called “T follicular helper” (TFH) cells that help select Ag-specific B cells. A second T cell subset, T follicular regulatory (TFR) cells, can act as repressors of the GC and Ab response but can also provide a helper ...
Qiang Chen, Alexander L Dent
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Follicular regulatory T cells infiltrated the ovarian carcinoma and resulted in CD8 T cell dysfunction dependent on IL‐10 pathway

International Immunopharmacology, 2019
A high Treg/CD8 T cell ratio in ovarian carcinoma was negatively associated with the prognosis of the patients. The human follicular regulatory T (Tfr) cells are a newly characterized subset of Treg cells with features of both follicular helper T (Tfh ...
Li Li, Yan Ma, Yuan Xu
semanticscholar   +1 more source

Identifying Follicular Regulatory T Cells by Confocal Microscopy

2017
Follicular regulatory T cells are a subset of Foxp3+ regulatory T cells that migrate into the B cell follicle after infection or immunization and modulate the germinal center response. The anatomical positioning of follicular regulatory T cells within the germinal center is a defining characteristic of this subset of regulatory T cells; because of this,
Ine, Vanderleyden, Michelle A, Linterman
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Alterations of the frequency and functions of follicular regulatory T cells and related mechanisms in HIV infection.

Journal of Infection, 2020
Human immunodeficiency virus (HIV) infection impairs both cellular and humoral immune system. Follicular regulatory T (Tfr) cells are a recently characterised subset of CD4+T cells.
Shuang Zhao, Wen Xu, B. Tu, W. Hong, Zheng Zhang, Wei-Wei Chen, Min Zhao   +6 more
semanticscholar   +1 more source

MicroRNA‐mediated regulation of T follicular helper and T follicular regulatory cell identity

Immunological Reviews, 2019
SummaryT follicular helper (Tfh) cells are critical mediators of germinal center (GC) formation and essential for potent humoral immunity. In contrast, T follicular regulatory (Tfr) cells, which share characteristics of both stimulatory Tfh cells and suppressive regulatory T (Treg) cells, restrain excessive GC responses.
Julia Maul, Dominik Alterauge, Dirk Baumjohann   +2 more
openaire   +2 more sources