Results 1 to 10 of about 19,954 (207)

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

eLife, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Michael A Gaviño, Danielle Wenemoser, Irving E Wang, Peter W Reddien   +3 more
doaj   +6 more sources

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice [PDF]

Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury.
Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki  Miwa, Takumi Era, Martin M. Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe   +26 more
doaj   +2 more sources

The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio [PDF]

Frontiers in Physiology, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Alexandra Baccam, Alexandra Baccam, Alexandra Baccam, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Marco Rocchi, Viviana Moresi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Sergio Adamo, Zhigang Xue, Dario Coletti, Dario Coletti, Dario Coletti   +16 more
doaj   +3 more sources

The Non-Linear Profile of Aging: U-Shaped Expression of Myostatin, Follistatin and Intermediate Signals in a Longitudinal In Vitro Murine Cell Sarcopenia Model [PDF]

Proteomes
Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence.
Janire Alonso-Puyo, Oihane Izagirre-Fernandez, Olatz Crende, Jesús Seco-Calvo, Ainhoa Fernandez-Atutxa, Diego Fernandez-Lazaro, Patricia Garcia-Gallastegi, Begoña Sanz   +7 more
doaj   +2 more sources

Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage

Cells, 2023
Activin A, a member of the TGF-beta superfamily, is a negative regulator of tubular regeneration after renal ischemia. Activin action is controlled by an endogenous antagonist, follistatin.
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima   +3 more
doaj   +1 more source

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Children, 2023
Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans.
Jaak Jürimäe, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann   +5 more
doaj   +1 more source

Pre- and Peri-/Post-Compaction Follistatin Treatment Increases In Vitro Production of Cattle Embryos. [PDF]

PLoS ONE, 2017
Our previous studies demonstrated that maternal (oocyte derived) follistatin (FST) expression is positively associated with bovine oocyte competence and exogenous follistatin treatment during the pre-compaction period of development (d 1-3 post ...
Guo Zhenhua, Sandeep K Rajput, Joseph K Folger, Liu Di, Jason G Knott, George W Smith   +5 more
doaj   +1 more source

Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying
I Gusti Putu Suka Aryana, I Made Arya Winangun   +1 more
doaj   +1 more source

Follistatin and follistatin-like 3 in metabolic disorders

Prostaglandins & Other Lipid Mediators, 2023
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders.
Weronika, Bielka, Agnieszka, Przezak, Andrzej, Pawlik   +2 more
openaire   +2 more sources

Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
openaire   +3 more sources