Results 1 to 10 of about 9,373 (145)

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice [PDF]

Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury.
Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki  Miwa, Takumi Era, Martin M. Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe   +26 more
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Higher serum follistatin levels are associated with increased vascular calcification in haemodialysis patients [PDF]

Frontiers in Endocrinology
IntroductionFollistatin is a secreted protein whose main role is antagonizing the activity of transforming growth factor β (TGF-β) superfamily members.
Conghui Liu, Conghui Liu, Aihua Zhang, Zhongxin Li   +3 more
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Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage

Cells, 2023
Activin A, a member of the TGF-beta superfamily, is a negative regulator of tubular regeneration after renal ischemia. Activin action is controlled by an endogenous antagonist, follistatin.
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima   +3 more
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Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Children, 2023
Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans.
Jaak Jürimäe, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann   +5 more
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Follistatin and follistatin-like 3 in metabolic disorders

Prostaglandins & Other Lipid Mediators, 2023
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders.
Weronika, Bielka, Agnieszka, Przezak, Andrzej, Pawlik   +2 more
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Pre- and Peri-/Post-Compaction Follistatin Treatment Increases In Vitro Production of Cattle Embryos. [PDF]

PLoS ONE, 2017
Our previous studies demonstrated that maternal (oocyte derived) follistatin (FST) expression is positively associated with bovine oocyte competence and exogenous follistatin treatment during the pre-compaction period of development (d 1-3 post ...
Guo Zhenhua, Sandeep K Rajput, Joseph K Folger, Liu Di, Jason G Knott, George W Smith   +5 more
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Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying
I Gusti Putu Suka Aryana, I Made Arya Winangun   +1 more
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Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
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The Role of Follistatin Domains in Follistatin Biological Action [PDF]

Molecular Endocrinology, 2004
Follistatin (FS) is an important regulator of pituitary FSH secretion through its potent ability to bind and bioneutralize activin. It also represents a prototype for binding proteins that control bioavailability of other TGFbeta-related growth factors such as the bone morphogenetic proteins.
Henry T, Keutmann, Alan L, Schneyer, Yisrael, Sidis   +2 more
openaire   +2 more sources

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Nature Communications, 2021
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that ...
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis   +41 more
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