Results 81 to 90 of about 12,893 (183)

Profiling of Extracellular Vesicles of Non‐Small Cell Lung Cancer Reveals Proteins Associated With Osimertinib Resistance

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Non‐invasive biomarkers are needed to further personalize EGFR tyrosine kinase inhibitor (EGFR TKI) osimertinib treatment in non‐small cell lung cancer (NSCLC) patients. By analysing the proteome of extracellular vesicles (EVs) isolated from an osimertinib resistant NSCLC cell line and from serum of patients given osimertinib in second line within the ...
Albano Cáceres‐Verschae, Petra Hååg, Sofia Joelsson, Per Hydbring, Bo Franzén, Ákos Végvári, Inger Johanne Z. Eide, Nupur Agarwal, Siddharth Sourabh Sahu, Fredrik Stridfeldt, Luigi De Petris, Apurba Dev, Simon Ekman, Odd Terje Brustugun, Rolf Lewensohn, Kristina Viktorsson   +15 more
wiley   +1 more source

The role of Follistatin-like 3 (Fstl3) in cardiac hypertrophy and remodelling

, 2011
Follistatins are extracellular inhibitors of TGF-β family ligands like activin A, myostatin and bone morphogenetic proteins. Follistatin-like 3 (Fstl3) is a potent inhibitor of activin signalling and antagonises the cardioprotective role of activin A in ...
Panse, Kalyani, Panse, Kalyani
core   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

Angiogenic Potential of Small Extracellular Vesicles Produced by Stimulated Mesenchymal Stromal Cells Under Hypoxic Conditions

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Regenerative vascular medicine research has positioned mesenchymal stromal cells (MSCs) as a leading candidate to treat ischemic diseases. Recent studies have highlighted the emerging role of small extracellular vesicles (sEVs) produced by MSCs in their own potential.
Nada Serhal, Bertrand Brassart, Lise Nannan, Sandra Audonnet, Christine Terryn, Gaël Poitevin, Pascale Cornillet‐Lefebvre, Florine Dubuisson, Hélène Peyret, Philippe Nguyen, Claire Tournois   +10 more
wiley   +1 more source

Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular failure and premature death. The identification of circulating biomarkers with prognostic utility is considered a priority.
Tetsuro Yokokawa, Olivier Boucherat, Sandra Martineau, Sarah‐Eve Lemay, Sandra Breuils‐Bonnet, Vinod Krishna, Shanker Kalyana‐Sundaram, Jey Jeyaseelan, François Potus, Sébastien Bonnet, Steeve Provencher   +10 more
doaj   +1 more source

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 11-23, January 2026.
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

Extracellular Vesicle‐Derived microRNAs as Fluid Biomarkers in Neurodegenerative Diseases: A Systematic Review

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Given the absence of curative treatments for neurodegenerative diseases, early detection and therapeutic intervention are critical to slowing disease progression. The last decade has seen accumulating evidence for microRNA dysregulation in circulating extracellular vesicles (EVs); however, assessing reproducibility between studies remains challenging ...
Aliyah Zaman, Sienna S. Drake, Alyson E. Fournier   +2 more
wiley   +1 more source

Adipose Mesenchymal Stem Cells Promote Wound Healing by Modulating Expression of SERPINE1 in Dermal Fibroblasts and Keratinocytes

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Adipose‐derived mesenchymal stem cells (ADSCs) have great potential in the realm of tissue repair and regenerative medicine. However, the exact effects of ADSCs on the healing of skin wounds and the underlying mechanisms remain unexplored. Here, we investigated the effects of ADSCs on fibroblasts and keratinocytes and their related molecular
YeHua Liang, Qinqian Sun, Jiaqi Sun, Mingyuan Xu, Jinghong Xu, Yijia Yu, Simona Ceccarelli   +6 more
wiley   +1 more source

Physiological Fluid Flow Moderates Fibroblast Responses to TGF-β1. [PDF]

, 2016
Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling and interstitial fluid movement.
Ahluwalia, Aykul, Ban, Chen, Del Galdo, Fumagalli, Glim, Handorf, Heldin, Hinsley, Honda, Jain, Kamato, Mammoto, Mazzei, Ng, Pan, Raghavan, Raghavan, Rodino-Klapac, Sbrana, Schultz, Shieh, Shieh, Swartz, Thannickal, Vered, Vinci, Vinci, Wiig, Wrighton   +30 more
core   +1 more source

Genomic Architecture of Nestmate Recognition Cues in the Desert Ant

Ecology and Evolution, Volume 15, Issue 12, December 2025.
This study reveals for the first time the genomic basis for the chemical cues used by social insects for nestmate recognition. We conducted a GWAS to identify QTLs that explain quantitative variation in cuticular hydrocarbons among colonies from a population of the desert ant Cataglyphis niger. ABSTRACT Nestmate recognition is the basis for cooperation
Pnina Cohen, Shani Inbar, Eyal Privman
wiley   +1 more source