Results 11 to 20 of about 19,656 (205)

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

eLife, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Michael A Gaviño, Danielle Wenemoser, Irving E Wang, Peter W Reddien   +3 more
doaj   +6 more sources

The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio [PDF]

Frontiers in Physiology, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Alexandra Baccam, Alexandra Baccam, Alexandra Baccam, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Marco Rocchi, Viviana Moresi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Sergio Adamo, Zhigang Xue, Dario Coletti, Dario Coletti, Dario Coletti   +16 more
doaj   +3 more sources

Differential expression of follistatin and FLRG in human breast proliferative disorders [PDF]

BMC Cancer, 2009
Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F, Grasso Giovanni, Muscettola Michela, Borges Lavinia E, Mencarelli Marzia, Ciarmela Pasquapina, Massai Lauretta, Couto Henrique L, Bloise Enrrico, Cassali Geovanni D, Petraglia Felice, Reis Fernando M   +11 more
doaj   +4 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Fibro-Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Orofacial and limb muscles differ in embryonic origin and regenerative capacity. Neuromuscular junction (NMJ) regeneration is critical for muscle restoration both histologically and functionally. The relative potential of orofacial and limb muscles to form postsynaptic apparatuses remains elusive.
Li R, Liu R, Huang Y, Wang Y, Cheng X, Li J, Zou S, Yin X.   +7 more
europepmc   +2 more sources

Circulating follistatin concentrations in adolescent PCOS: Divergent effects of randomized treatments

Frontiers in Endocrinology, 2023
PurposeFollistatin is a glycoprotein that represses members of the transforming growth factor-β superfamily including activin. Higher follistatin levels have been associated with an increased risk for type 2 diabetes and with polycystic ovary syndrome ...
Marta Díaz, Marta Díaz, Francis de Zegher, Lourdes Ibáñez, Lourdes Ibáñez   +4 more
doaj   +1 more source

Follistatin and Follistatin Like‐3 Differentially Regulate Adiposity and Glucose Homeostasis [PDF]

Obesity, 2011
Transforming growth factor‐β superfamily ligands, including activin and myostatin, modulate body composition, islet function, and glucose homeostasis. Their bioactivity is controlled by the antagonists follistatin (FST) and FST like‐3 (FSTL3). The hypothesis tested was that FST and FSTL3 have distinct roles in regulating body composition, glucose ...
Melissa L, Brown, Lara, Bonomi, Nathan, Ungerleider, Jessica, Zina, Fuminori, Kimura, Abir, Mukherjee, Yisrael, Sidis, Alan, Schneyer   +7 more
openaire   +2 more sources

Grass Carp Follisatin: Molecular Cloning, Functional Characterization, Dopamine D1 Regulation at Pituitary Level, and Implication in Growth Hormone Regulation

Frontiers in Endocrinology, 2017
Activin is involved in pituitary hormone regulation and its pituitary actions can be nullified by local production of its binding protein follistatin. In our recent study with grass carp, local release of growth hormone (GH) was shown to induce activin ...
Roger S. K. Fung, Bai Jin, Mulan He, Karen W. Y. Yuen, Anderson O. L. Wong   +4 more
doaj   +1 more source

Immunostaining of βA-Activin and Follistatin Is Decreased in HPV(+) Cervical Pre-Neoplastic and Neoplastic Lesions

Viruses, 2023
The activin–follistatin system regulates several cellular processes, including differentiation and tumorigenesis. We hypothesized that the immunostaining of βA-activin and follistatin varies in neoplastic cervical lesions.
Victor Jesus Huaringa Payano, Lara Verônica de Araújo Lopes, Larissa Rodrigues Peixoto, Keila Alves da Silva, Tania Maria Ortiga-Carvalho, Alexandre Tafuri, Annamaria Ravara Vago, Enrrico Bloise   +7 more
doaj   +1 more source

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]

, 2013
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee, Alan L. Schneyer, Andrew A. Pitsillides, Archambeault, Baker, Bakker, Bartholin, Bastow, Besset, Brehm, Chan, Cohen, Cooke, Cooke, Cooke, Coultas, Coussens, Dierich, Do, Fujita, Gill, Hardwick, Itman, Jan Seebacher, Johnston, Judit Villen, Karla J. Oldknow, Kato, Kato, Kooy, Kumar, Lee, Matzuk, Mukherjee, Nef, Noriega, Parvinen, Peter J. O'Shaughnessy, Salisbury, Shang, Sharpe, Sidis, Slegtenhorst-Eegdeman, St-Pierre, Steeno, Steven P. Gygi, Tanimoto, Tapasree Goswami, Tolonen, Tsuchida, Turek, Wilhelm, Wreford, Xia, Yang   +54 more
core   +1 more source