Results 11 to 20 of about 19,954 (207)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
The Role of Follistatin Domains in Follistatin Biological Action [PDF]
Molecular Endocrinology, 2004 Follistatin (FS) is an important regulator of pituitary FSH secretion through its potent ability to bind and bioneutralize activin. It also represents a prototype for binding proteins that control bioavailability of other TGFbeta-related growth factors such as the bone morphogenetic proteins.
Henry T, Keutmann +2 more
openaire +2 more sources
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
Nature Communications, 2021 Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that ...
Chuanyan Wu +41 more
doaj +1 more source
Frontiers in Endocrinology, 2023 PurposeFollistatin is a glycoprotein that represses members of the transforming growth factor-β superfamily including activin. Higher follistatin levels have been associated with an increased risk for type 2 diabetes and with polycystic ovary syndrome ...
Marta Díaz +4 more
doaj +1 more source
Follistatin and Follistatin Like‐3 Differentially Regulate Adiposity and Glucose Homeostasis [PDF]
Obesity, 2011 Transforming growth factor‐β superfamily ligands, including activin and myostatin, modulate body composition, islet function, and glucose homeostasis. Their bioactivity is controlled by the antagonists follistatin (FST) and FST like‐3 (FSTL3). The hypothesis tested was that FST and FSTL3 have distinct roles in regulating body composition, glucose ...
Melissa L, Brown +7 more
openaire +2 more sources
Viruses, 2023 The activin–follistatin system regulates several cellular processes, including differentiation and tumorigenesis. We hypothesized that the immunostaining of βA-activin and follistatin varies in neoplastic cervical lesions.
Victor Jesus Huaringa Payano +7 more
doaj +1 more source
Geometric control of myogenic cell fate. [PDF]
, 2006 This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells.
Conboy IM +9 more
core +3 more sources
Frontiers in Endocrinology, 2017 Activin is involved in pituitary hormone regulation and its pituitary actions can be nullified by local production of its binding protein follistatin. In our recent study with grass carp, local release of growth hormone (GH) was shown to induce activin ...
Roger S. K. Fung +4 more
doaj +1 more source
The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims The role of serum myokine levels in sarcopenia and the outcome of hepatocellular carcinoma (HCC) patients are not clear. This study investigated the serum levels of myostatin, follistatin, and interleukin-6 (IL-6) in HCC patients and ...
Kanghyug Choi +9 more
doaj +1 more source
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]
, 2012 The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core +1 more source