Follistatin-Like Proteins: Structure, Functions and Biomedical Importance
Biomedicines, 2021 Main forms of cellular signal transmission are known to be autocrine and paracrine signaling. Several cells secrete messengers called autocrine or paracrine agents that can bind the corresponding receptors on the surface of the cells themselves or their ...
Olga K. Parfenova +2 more
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Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men [PDF]
, 2011 Peer ...
A. DeVries +41 more
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Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization [PDF]
Endocrinology, 2001 Follistatin-related protein is a recently discovered glycoprotein that is highly homologous in both primary sequence and exon/intron domain structure to the activin-binding protein, follistatin. We explored their potential for functional redundancy by investigating the relative affinities and kinetics of their interactions with activin, bone ...
D V, Tortoriello +4 more
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The use of genes for performance enhancement: doping or therapy? [PDF]
, 2011 Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation ...
Collares, T. F. +4 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on FST (follistatin), with data on DNA, on the protein encoded, and where the gene is implicated.
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Differential Biosynthesis and Intracellular Transport of Follistatin Isoforms and Follistatin-Like-3 [PDF]
Endocrinology, 2005 Follistatin (FST) and FST-like-3 (FSTL3) are structurally related proteins that bind and neutralize activin and closely related members of the TGFβ superfamily. Three FST isoforms (FST288, FST303, and FST315) are produced from the Fst gene that are primarily secreted proteins. FSTL3 is secreted, but is also observed within the nucleus of most cells. We
Seiichiro, Saito +4 more
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Cloning and analysis of promoter of Paralichthys olivaceus Follistatin gene
浙江大学学报. 农业与生命科学版, 2007 In order to study the tissue expression character of Follistatin gene in marine fish, the promoter of Paralichthys olivaceus Follistatin gene was isolated by PCR, and the sequence was analyzed; the function of Follistatin gene on the development of ...
LIU Qing-hua +4 more
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Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts. [PDF]
PLoS ONE, 2013 Follistatin is a potent regulator of the inflammatory response and binds to and inhibits activin A action. Activin A is a member of the TGFβ protein superfamily which has regulatory roles in the inflammatory response and in the fibrotic process. Fibrosis
Helen B Forrester +5 more
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Inactivating hepatic follistatin alleviates hyperglycemia [PDF]
Nature Medicine, 2018 Unsuppressed hepatic glucose production (HGP) contributes substantially to glucose intolerance and diabetes, which can be modeled by the genetic inactivation of hepatic insulin receptor substrate 1 (Irs1) and Irs2 (LDKO mice). We previously showed that glucose intolerance in LDKO mice is resolved by hepatic inactivation of the transcription factor ...
Rongya Tao +12 more
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PLoS ONE, 2014 ContextThe Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth.ObjectiveTo analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and ...
Silvia Näf +8 more
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