Results 51 to 60 of about 19,954 (207)

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Frontiers in Endocrinology, 2021
Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases.
Shehla Pervin, Shehla Pervin, Srinivasa T. Reddy, Srinivasa T. Reddy, Rajan Singh, Rajan Singh, Rajan Singh   +6 more
doaj   +1 more source

An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth [PDF]

, 2012
Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation, and are responsible for the continuous regeneration of tissues such as hair, skin, and gut.
Alonso, Maria T, Chuong, Cheng-Ming, Felszeghy, Szabolcs, Maas, Richard Louis, Plikus, Maksim V, Schimmang, Thomas, Suomalainen, Marika, Thesleff, Irma, Wang, Xiu-Ping, Zelarayan, Laura C   +9 more
core   +1 more source

Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]

, 1999
Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van, Aken, B.E. (Benien) van, Engelse, M.A. (Marten), Neele, J.M., Pannekoek, H. (Hans), Schaik, R.H.N. (Ron) van, Vries, C.J.M. (Carlie) de   +6 more
core   +3 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury

Cells
Activin A is known to impede tubular repair following renal ischemia, whereas exogenous follistatin, an activin A antagonist, has been shown to ameliorate kidney damage in rats.
Izumi Nagayama, Kaori Takayanagi, Daisuke Nagata, Hajime Hasegawa, Akito Maeshima   +4 more
doaj   +1 more source

Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice

Cells, 2022
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development.
Jing Li, Yan Qi, Ke Yang, Linjing Zhu, Xueling Cui, Zhonghui Liu   +5 more
doaj   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

Interleukin‐18 levels are associated with disease course in patients with Still's disease treated with IL‐1 inhibitors

Arthritis &Rheumatology, Accepted Article.
Objective To evaluate the prognostic utility of circulating Interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in Still's disease (SD) patients receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan, Manuela Pardeo, Ivan Caiello, Claudia Bracaglia, Arianna de Matteis, Valentina Matteo, Elena Loricchio, Fabrizio De Benedetti, Giusi Prencipe   +8 more
wiley   +1 more source

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome [PDF]

, 1995
MRF4 (herculin/Myf-6) is one of the four member MyoD family of transcription factors identified by their ability to enforce skeletal muscle differentiation upon a wide variety of nonmuscle cell types.
Miner, Jeffrey H., Patapoutian, Ardem, Stark, Kevin, Wang, Shuling, Wold, Barbara, Yoon, Jeong Kyo   +5 more
core  

Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]

, 2018
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
core   +1 more source