Results 61 to 70 of about 3,503,938 (259)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Electrical interface design for additively manufactured polymer anodes for biophotovoltaic systems

Frontiers in Microbiology
IntroductionReliable electrical interfacing between additively manufactured conductive polymer anodes and external circuits remains a key challenge in biophotovoltaic (BPV) systems, particularly due to debonding failures during operation. This study aims
Maira Anam, Geoffrey Rivers, Rachel Louise Gomes, Ricky Wildman, Helena I. Gomes   +4 more
doaj   +1 more source

Follow‐up of the re‐evaluation of polyglycerol esters of fatty acids (E 475) as a food additive

EFSA Journal, 2022
Polyglycerol esters of fatty acids (PEFA, E 475) was re‐evaluated in 2017 by the former EFSA Panel on Food Additives and Nutrient sources added to Food (ANS). As a follow‐up to this assessment, in this opinion, the Panel on Food Additives and Flavouring (
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Detlef Wölfle, Matthew Wright, Karlien Cheyns, Manuela Mirat, Ana Maria Rincon, Peter Fürst   +21 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D3

Poultry Science
: Four experiments were performed to investigate the role of the mitogen-activated protein kinase (MAPK) signaling pathway in intestinal absorption of phosphorus (P) and calcium (Ca) in broiler chickens.
Jincheng Han, Xianliang Lv, Lei He, Mengyuan Liu, Hongxia Qu, Li Xi, Liao Zhang, Bingbing Ma, Chuanxin Shi, Guangli Yang, Zhixiang Wang   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Atomic-Scale Mechanisms of Catalytic Recombination and Ablation in Knitted Graphene Under Hyperthermal Atomic Oxygen Exposure

C
Effective ablative thermal protection systems are essential for ensuring the structural integrity of hypersonic vehicles subjected to extreme aerothermal loads.
Yating Pan, Yunpeng Zhu, Donghui Zhang, Ning Wei   +3 more
doaj   +1 more source

Physicochemical Characterization of the Pristine E171 Food Additive by Standardized and Validated Methods

Nanomaterials, 2020
E171 (titanium dioxide) is a food additive that has been authorized for use as a food colorant in the European Union. The application of E171 in food has become an issue of debate, since there are indications that it may alter the intestinal barrier ...
Eveline Verleysen, Nadia Waegeneers, Frédéric Brassinne, Sandra De Vos, Isaac Ojea Jimenez, Stella Mathioudaki, Jan Mast   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Guidance for submission for food additive evaluations

This guidance document refers to the applications for authorisation of a new food additive or to a modification of an already authorised food additive, combining in a single document the description of the data requirements and their context, and also a ...
Waalkens-Berendsen I, Mortensen A, Mosesso P, Tobback P, Dusemund B, Crebelli R, Woutersen R, Gundert-Remy U, Gilbert J, König J, Galtier P, Lambré C, Stankovic I, Wright MC, Aguilar F, Leblanc J-C, Parent-Massin D, Gott DM   +17 more
core   +2 more sources