Results 251 to 260 of about 31,268,655 (339)

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

A randomized, placebo-controlled first-in-human study of oral TQS-168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect. [PDF]

Clin Transl Sci
Hannestad J, Smith S, Lam A, Hurt J, Harada N, Kim R, Das A, Brunello J, Whitaker G, Chalmers D, Senjoti F, Lin W, Coghill J, Bansal Y, Sidhu S, Zann V, Liu E.   +16 more
europepmc   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Randomized, double-blind, phase 1a single-ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers. [PDF]

Clin Transl Sci
Schmidt WK, Cortés-Puch I, McReynolds CB, Croston GE, Hwang SH, Yang J, Pedersen TL, Wagner KM, Pham TT, Hunt T, Hammock BD.   +10 more
europepmc   +1 more source

Safety, pharmacokinetics, and food effect of sudapyridine (WX-081), a novel anti-tuberculosis candidate in healthy Chinese subjects. [PDF]

Clin Transl Sci
Yu C, Qian H, Wu Q, Zou Y, Ding Q, Cai Y, Liang L, Xu J, Li L, Zan B, Li Y, Liu Y.   +11 more
europepmc   +1 more source

Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed-dose combination tablets versus the use of single-component tablets in healthy subjects. [PDF]

Pharmacol Res Perspect
Ford JL, Sabet A, Natarajan J, Stieltjes H, Chao DL, Goyal N, Csonka D.   +6 more
europepmc   +1 more source

Key Factors for Improving Predictive Accuracy and Avoiding Overparameterization of the PBPK Absorption Model in Food Effect Studies of Weakly Basic Water-Insoluble Compounds in Immediate Release Formulations. [PDF]

Pharmaceutics
Zhang M, Zhang S, Wang L, Zhang Z, Hu Q, Liu D.   +5 more
europepmc   +1 more source