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The Effect of Food on the Pharmacokinetics of Zileuton
Clinical Pharmacokinetics, 1995The present study was undertaken to assess the effect of food on the pharmacokinetic parameters of zileuton. In a nonblinded crossover study, 18 healthy male volunteers who had fasted overnight were randomised to receive a single oral dose of zileuton 600mg in the presence or absence of food consisting of a standardised breakfast on the following ...
W M, Awni +4 more
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THE EFFECT OF FOOD ON CYCLOSPORINE ABSORPTION
Transplantation, 1985The effect of food on the absorption of cyclosporine was evaluated in 18 recipients of cadaveric renal transplants. Cyclosporine was administered orally with a standard hospital breakfast on one study day and without breakfast on the alternate study day.
R J, Ptachcinski +5 more
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Effect of Food on the Bioavailability of Bendroflumethiazide
Acta Medica Scandinavica, 1978ABSTRACT. Bendroflumethiazide (BFT), 10 mg, was given orally to eight subjects after fasting overnight and together with a meal. Concentrations of the diuretic in plasma and urine were determined by GLC. As judged by AUC and urinary recovery of BFT, the bioavailability of the diuretic was not influenced by concomitant intake of a meal.
B, Beermann +2 more
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Effects of food on the pharmacokinetics of sparfloxacin
Clinical Therapeutics, 1999Sparfloxacin, a fluoroquinolone with a broad antimicrobial spectrum and long elimination half-life, is indicated for the treatment of community-acquired pneumonia and acute bacterial exacerbations of chronic bronchitis in adult patients. The present study was undertaken to determine the effects of skim milk and a high-fat breakfast without milk on the ...
R D, Johnson +4 more
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Effects of Food on Drug Absorption
Annual Review of Nutrition, 1989This chapter provides an update on drug-food interactions reported in the literature during the past five years. The number of studies examining this phenomenon has increased dramatically, and many of the results of these studies have been unpredictable and spectacular.
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Effect of Food on Bioavailability of Rifampicin
The Journal of Clinical Pharmacology, 1983Abstract: The area under the plasma concentration‐time curve of rifampicin was determined with and without food administration in six healthy male volunteers. Rifampicin (10 mg/kg) was administered orally in the fasting state on one occasion and following a wheat‐based breakfast on another.
K, Polasa, K, Krishnaswamy
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Effects of Food on the Pharmacokinetics of Methylphenidate
Pharmaceutical Research, 2001To test the hypothesis that the pharmacokinetics of d-methylphenidate (d-MPH) would be altered by food ingested before administration of an immediate release formulation (dl-MPH- IR) but not when food is ingested before a slow release formulation (dl-MPH-SR).A randomized, four-phase, open label, crossover design was conducted in 24 healthy men who each
K K, Midha +4 more
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Effects of Food on Ethanol Metabolism
Drug Metabolism and Drug Interactions, 2002The goals of the present study were (1) to obtain ethanol pharmacokinetic data from fed dogs, and (2) perform Monte Carlo simulation to determine the effect of food on pharmacokinetic model parameter values. To a cohort of five fed dogs, 1 g ethanol per km body weight was administered as a gavage of 20% w/v ethanol solution.
David, Whitmire +2 more
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Lipid based delivery of Efavirenz: An answer to its erratic absorption and food effect
European Journal of Pharmaceutical Sciences, 2018The current investigation entails systematic development of EFV (Efavirenz) loaded isotropic mixture prepared with long chain triglycerides for obliterating food associated variability and minimizing the erratic absorption behavior. For this purpose, the
Sunil Kamboj, Sheshank Sethi, V. Rana
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Gastrointestinal effects of food carbohydrate
The American Journal of Clinical Nutrition, 1995Dietary carbohydrate may be divided into monosaccharides and disaccharides (sugars), oligosaccharides [degree of polymerization (DP) 3-9], and polysaccharides (DP > 10). Their physiological properties and health benefits depend on the site, rate, and extent of their digestion or fermentation in the gut.
J H, Cummings, H N, Englyst
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