Results 61 to 70 of about 17,331 (269)
Advanced Science, EarlyView.In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu +16 more
wiley +1 more source
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Réappropriation des systèmes alimentaires par les citoyens : une logique de Communs urbains
Netcom, 2017 The purpose of this research note is to understand the notion of Commons in terms of the re-appropriation by citizens of the systems of production and distribution of food. In this reflection we will question the role of digital tools, and above all, the
Myriam Bouré
doaj +1 more source
Revitalising local economies : how food hubs can help
, 2019 This is a short document outlining how food hubs can help revitalise local economies. The Guidance Note is aimed at hub operators, local food entrepreneurs, third sector workers, policy makers and funders who are interested in strengthening the ...
Reynolds, C., Guzman, P.
core
, 2021 Our food systems are under pressure and failing us. This failure includes the inability to (a) produce and deliver high-quality diets to meet nutritional needs, (b) produce equal and equitable benefits, and (c) mitigate negative consequences.
Beesabathuni, Kalpana +12 more
core +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Food hubs for the sustainable short food supply chain in west java
, 2021 : This study aims to propose a feasible concept of Food Hubs that can be implemented in West Java for the sustainable short food supply chain and to determine significant differences of value chain of food hub and the existing value chain that ...
Putri, Rezki Ananda, Handayati, Yuanita
core
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
LogisticsBackground: Agriculture plays a key role in Colombia’s economy. However, the sector faces persistent logistics, infrastructure, and supply chain integration challenges that hinder its development.
Juan Camilo Vargas-Muñoz +3 more
doaj +1 more source