Results 111 to 120 of about 60,842 (306)

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

The baked side: Cow's milk and egg protein threshold dose distributions in children reacting to baked milk and baked egg

World Allergy Organization Journal
Background: Children allergic to milk and egg, but tolerant to baked products, display higher reactivity thresholds than the general population of children allergic to milk and egg.
Rocco Luigi Valluzzi, MD, Carla Riccardi, MD, Sara Urbani, MD, Davide Ursi, MD, Deborah Zavettieri, MD, Francesco Di Girolamo, PhD, Lamia Dahdah, MD, Veronica Calandrelli, PharmD, Vincenzo Fierro, MD, Alessandro Fiocchi, MD   +9 more
doaj   +1 more source

FURTHER OBJECTIVE STUDIES IN CHILDREN WITH HYPERSENSITIVITY TO FOODS [PDF]

, 1977
S. Allan Bock, Charles D. May
openalex   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Allergenic protein-induced type I hypersensitivity models: a review

Frontiers in Allergy
ContextType I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous ...
Yanhua Feng, Liangyu Xu, Jinming Zhang, Jinlian Bin, Jinlian Bin, Xialing Pang, Sheng He, Sheng He, Lei Fang, Lei Fang   +9 more
doaj   +1 more source

Conservative management of Oral Submucous Fibrosis in early and intermediate stage

Journal of Oral Biology and Craniofacial Research, 2018
Aims & objective: To evaluate the efficacy of combined intralesional injection of Hyaloronidase and Triamcinolone with third molar removal in early and intermediate stage (Stage II & III) of Oral Submucous Fibrosis (OSMF) for improvement in mouth
Sachin Rai, Vidya Rattan, Akshat Gupta, Praveen Kumar   +3 more
doaj   +1 more source

A Case Report of Angioedema and Anaphylactic Shock Induced by Ingestion of Polyethylene Glycol [PDF]

, 2020
Introduction: We report one of few documented cases of a severe anaphylactic reaction with angioedema to polyethylene glycol (PEG).Case Report: The patient presented 30 minutes after onset of his symptoms and quickly developed hypoxia and hypotension ...
Osborn, Lesley, Rossi, Amy
core  

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Molecular and behavioral mechanisms mediating paclitaxel-induced changes in affect-like behavior in mice [PDF]

, 2019
The antineoplastic paclitaxel is associated with negative affective outcomes, such as depression, anxiety, and decreased quality of life during treatment and convalescence. With the Baby Boomer population approaching peak cancer age, it is dire that the
Alkhlaif, Yasmin, Damaj, Imad, Meade, Julia, Obeng, Samuel, Selley, Dana E., Toma, Wisam B   +5 more
core   +1 more source

Root coverage using a microsurfaced acellular dermal matrix: A retrospective case series

Clinical Advances in Periodontics, EarlyView.
Abstract Background Acellular dermal matrices (ADMs) have been used for root coverage for over 25 years, yet few advancements have improved clinical outcomes or reduced complications. This case series evaluated the use of a novel microsurfaced ADM (mADM), which features a microtextured surface designed intended to promote healing and improve graft ...
Yu‐Chang Wu, Guo‐Liang Cheng, Shaun Rotenberg   +2 more
wiley   +1 more source