Results 221 to 230 of about 56,919 (302)
ACR Open Rheumatology, Volume 7, Issue 8, August 2025.Objective Retroperitoneal fibrosis (RPF) complicated by mediastinal fibrosis (MF) is rare but fatal. We aimed to explore the features and indicators of poor prognosis for the population of those affected. Methods Patients with idiopathic RPF were recruited in Peking University International Hospital.
Yishan Ding +8 more
wiley +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Comprehensive Physiology, Volume 15, Issue 4, August 2025.Integrative cellular signaling triggered by the impaired glucose tolerance or impaired insulin sensitivity, mitochondrial dysfunction, mediated by an intricate cellular signaling orchestrated by TGF‐ß1‐JNK and TNF‐α‐MAPK increased extracellular matrix (ECM) remodeling pathways, and loss of type I muscle fibers in LRT models. Adapted from Lessard et al.
Vinicius Guzzoni +10 more
wiley +1 more source
European Journal of Immunology, Volume 55, Issue 8, August 2025.This study discovered the small molecule 9‐methoxy‐6‐methylindolo[3,2‐b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL‐4, IL‐5, and IL‐13) and promotes the iTreg phenotype by inhibiting Wnt/β‐catenin signaling through NKD2 ...
Jiajun He +9 more
wiley +1 more source
Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.ABSTRACT Background Sarcopenia, an age‐related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. Nucleotides (NTs) supplementation is a potential strategy for preventing age‐related sarcopenia as evidence suggests that NTs declined in muscles with aging, and 5′‐CMP, 5′‐UMP can ...
Xin Wu +7 more
wiley +1 more source
Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer
MedComm, Volume 6, Issue 8, August 2025.Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla +8 more
wiley +1 more source
GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4. [PDF]
J Biol Chem, 2014 Huo X +7 more
europepmc +1 more source
A case of Axenfeld-Rieger syndrome with neuroradiological abnormalities. [PDF]
Radiol Case RepOhkubo Y +9 more
europepmc +1 more source