Results 231 to 240 of about 56,919 (302)

Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport

MedComm, Volume 6, Issue 8, August 2025.
Crizotinib inhibits CD147‐MCT1‐mediated lactate transport, suppressing melanoma growth and immune escape, prevents M2 macrophage polarization, and enhances immunotherapy by reducing CXCL13 via histone lactylation. ABSTRACT Lactate is a vital metabolite in cancer, significantly impacting tumor progression, metastasis, and overall survival.
Zhe Zhou, Xu Zhang, Susi Zhu, Waner Liu, Yeye Guo, Siyu Xiong, Cong Peng, Xiang Chen   +7 more
wiley   +1 more source

Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways.

Development, 2016
Ahmad SM, Bhattacharyya P, Jeffries N, Gisselbrecht SS, Michelson AM.   +4 more
europepmc   +1 more source

Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells. [PDF]

Helicobacter, 2012
Tabassam FH, Graham DY, Yamaoka Y.
europepmc   +1 more source

The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

, 2006
Il‐man Kim, Timothy Ackerson, Sneha Ramakrishna, Maria Tretiakova, I‐Ching Wang, Tanya V. Kalin, Michael L. Major, Galina A. Gusarova, Helena M. Yoder, Robert H. Costa, Vladimir V. Kalinichenko   +10 more
openalex   +1 more source

Peptide Drug: Design and Clinical Applications

MedComm, Volume 6, Issue 8, August 2025.
The diagram illustrates the role of poly peptides in various biological processes. It highlights their involvement in glucose, lipid, and amino acid metabolism, as well as in antitumor and antiviral immunity. Additionally, poly peptides are linked to disease diagnosis and prognosis, emphasizing their significance in healthcare.
Yaqi Han, YunKui Zhang, Han Li, Zhongliang Ma, Yanmao Wang   +4 more
wiley   +1 more source

GDF11 downregulates FOXP3 in T-cell acute lymphoblastic leukemia-derived cells and associates with restraining aggressiveness. [PDF]

Oncol Res
SáNCHEZ-RODRíGUEZ M, Lazzarini-Lechuga R, Souza-Arroyo V, Bucio-Ortiz L, Miranda-Labra RU, Gerardo-RAMíREZ M, PáEZ-Arenas A, Vergara-Mendoza M, CONCEPCIóN GUTIéRREZ-Ruiz M, Escobedo-Calvario A, Gomez-Quiroz LE.   +10 more
europepmc   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Regulation of retinal homeobox gene transcription: Implication of involvement of forkhead transcription factors

, 2006
Holly E. Moose, Lisa E. Kelly, Reyna I. Martinez, Heithem M. El‐Hodiri   +3 more
openalex   +1 more source

T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation

MedComm, Volume 6, Issue 8, August 2025.
• SHP2 deficiency in T cells could alleviate both psoriasis‐like skin lesion and adoptive transfer colitis. • SHP2 deficiency in T cells promotes the differentiation toward Treg, thus regulating the balance of Th17/Treg. • SHP2 may become a promising common therapeutic target in the treatment of autoimmune diseases.
Shuqiong Zhang, Zijun Ouyang, Zhidan Fan, Haiyan Sun, Haiguo Yu, Xingxin Wu, Yang Sun, Fenli Shao   +7 more
wiley   +1 more source

Nanoparticle‐Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy‐Mediated CD8+T Cell Exhaustion

MedComm, Volume 6, Issue 8, August 2025.
CD74highCD7high exhausted CD8+T cells were characterized by ScRNA‐seq, and their association with SLE diagnostic indicators was evaluated. NSUN4 was screened as a therapeutic target by integrative analysis of scRNA‐seq and m5C‐seq, and its role in mitochondrial dysfunction was investigated in cultured CD8+T cells in vitro. The therapeutic effect of LPH‐
Bincheng Ren, Kaini He, Ning Wei, Shanshan Liu, Xiaoguang Cui, Xin Yang, Xiaojing Cheng, Tian Tian, Ru Gu, Xueyi Li   +9 more
wiley   +1 more source