Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice
FASEB BioAdvances, Volume 8, Issue 2, February 2026.Denervation induces mitochondrial dysfunction and oxidative stress in skeletal muscle. In PolG(+/mut) mice, denervation led to reduced mitochondrial DNA copy number and a pronounced upregulation of the antioxidant enzyme catalase, despite comparable levels of muscle atrophy, mitochondrial content, and mitochondrial dynamics‐related proteins compared to
Takanaga Shirai +6 more
wiley +1 more source
Lifespan‐Extending Endogenous Metabolites
Aging Cell, Volume 25, Issue 2, February 2026.Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes. [PDF]
J Biol Chem, 2016 Yalley A +4 more
europepmc +1 more source
The Regulation and Function of the Forkhead Transcription Factor, Forkhead Box O1, Is Dependent on the Progesterone Receptor in Endometrial Carcinoma [PDF]
, 2007 Erin C. Ward +8 more
openalex +1 more source
Targeting forkhead box transcription factors FOXM1 and FOXO in leukemia (Review).
Oncology Report, 2014 Hong Zhu
semanticscholar +1 more source
Aging Reshapes γ/δ T‐Cell Immunity Through a Type I Interferon–Foxo1 Axis
Aging Cell, Volume 25, Issue 2, February 2026.Aging reshapes the peripheral γ/δ T‐cell compartment by promoting the expansion and enhanced IL‐17–driven activity of innate‐like γ/δ T cells in secondary lymphoid organs. This remodeling is controlled by type I interferon–dependent downregulation of Foxo1, linking aging to heightened pro‐inflammatory γ/δ T‐cell responses.
Aurélie Durand +7 more
wiley +1 more source
Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence [PDF]
, 2010 Peter L.J. de Keizer +9 more
openalex +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation [PDF]
, 2011 Mónica Álvarez‐Fernández +4 more
openalex +1 more source