Results 241 to 250 of about 56,919 (302)

Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway. [PDF]

Neuroreport
Zhang G, Xu W.
europepmc   +1 more source

An INS‐1 832/13 𝛽‐Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose‐Stimulated Insulin Secretion

PROTEOMICS, Volume 25, Issue 15, Page 13-26, August 2025.
ABSTRACT Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucose‐stimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INS‐1 832/13 beta cells that were short‐term stimulated with 11 different glucose concentrations from 0 to 20 mM, quantifying the response of 3703 proteins ...
Nina Stremmel, Oliver Lemke, Kathrin Textoris‐Taube, Daniela Ludwig, Michael Mülleder, Julia Muenzner, Markus Ralser   +6 more
wiley   +1 more source

Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Respiratory diseases are associated with high mortality worldwide. Respiratory infections can lead to the emergence of chronic respiratory diseases. Scientists are constantly striving to identify new therapies with reduced side effects.
Kazi Ahsan Ahmed, Nusrat Afrin, Popy Ghosh, Irin Amin Heya, Sajidur Rahman Akash, Akhi Moni, Mohammad Nazrul Islam, Md. Golzar Hossain, Alessandra Sinopoli, Md Abdul Hannan, Md Jamal Uddin   +10 more
wiley   +1 more source

Immune Modulation Through Stereotactic Radiotherapy: The Role of TBX21, GATA-3, FoxP3, and RORɣt. [PDF]

Medicina (Kaunas)
Ucgul AN, Bora H, Yaz Aydin G, Gulbahar O, Koken UH.   +4 more
europepmc   +1 more source

Dual Role of MtHAC‐1 in Regulating Cellulase and Xylanase Production in Myceliophthora thermophila

Microbial Biotechnology, Volume 18, Issue 8, August 2025.
Through a combination of gene deletion, overexpression analyses, and electrophoretic mobility shift assays, we demonstrate that MtHac‐1 acts as a dual‐function regulator of cellulase and xylanase production, directly modulating the expression of major cellulase and xylanase genes, as well as the regulatory gene Mtxyr1, through promoter binding ...
Yapeng Lai, Juan Wang, Ning Xie, Gang Liu, Donnabella C. Lacap‐Bugler   +4 more
wiley   +1 more source

Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression. [PDF]

J Biol Chem, 2011
Venugopalan SR, Li X, Amen MA, Florez S, Gutierrez D, Cao H, Wang J, Amendt BA.   +7 more
europepmc   +1 more source

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

British Journal of Pharmacology, Volume 182, Issue 16, Page 3903-3922, August 2025.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács, Tamás Kovács, András Lánczky, Ágnes Paál, Zsombor I. Hegedűs, Nabil V. Sayour, Lilla Szabó, Andrea Kovács, Giampaolo Bianchini, Péter Ferdinandy, Alberto Ocana, Zoltán V. Varga, János Tibor Fekete, Balázs Győrffy   +13 more
wiley   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

The transcription factor FOXQ1 in cancer. [PDF]

Cancer Metastasis Rev
Koch S.
europepmc   +1 more source

Exploring the Single‐Cell Dynamics of FOXM1 Under Cell Cycle Perturbations

Cell Proliferation, Volume 58, Issue 8, August 2025.
The varied FOXM1 dynamic patterns reveal significant differences in cellular responses to the same stimuli at the single‐cell level. This emphasises the relationship between cue, signal and response as influenced by different drug types and concentrations.
Tooba Jawwad, Maliwan Kamkaew, Kriengkrai Phongkitkarun, Porncheera Chusorn, Supawan Jamnongsong, Eric W.‐F. Lam, Somponnat Sampattavanich   +6 more
wiley   +1 more source