Results 251 to 260 of about 56,919 (302)

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, Volume 58, Issue 8, August 2025.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Combined inhibition of protein kinase B and enhancer of zeste homolog 2: a novel strategy to induce triple-negative breast cancer cell death. [PDF]

Mol Biomed
Zhu X, Wang Y, Zhang L.
europepmc   +1 more source

Environmental factors affecting RNAi efficacy: Temperature but not plant cultivar influences Colorado potato beetle's response to insecticidal dsRNA

Insect Molecular Biology, Volume 34, Issue 4, Page 581-592, August 2025.
Colorado potato beetle's RNA interference (RNAi) response was enhanced when insecticidal dsactin was consumed at high temperatures. The enhanced RNAi outcomes at high temperatures were not a function of dose or the expression of core RNAi genes. The potato cultivar consumed by Colorado potato beetle larvae did not affect RNAi outcomes, but larvae did ...
Mike Darrington, Jason Solocinski, Sophia K. Zhou, Melise C. Lecheta, Subba Reddy Palli, Yolanda H. Chen, Nicholas M. Teets   +6 more
wiley   +1 more source

DNA methyltransferase 1/miR-342-3p/Forkhead box M1 signaling axis promotes self-renewal in cervical cancer stem-like cells <i>in vitro</i> and nude mice models. [PDF]

World J Stem Cells
Cao XZ, Zhang YF, Song YW, Yuan L, Tang HL, Li JY, Qiu YB, Lin JZ, Ning YX, Wang XY, Xu Y, Lin SQ.   +11 more
europepmc   +1 more source

CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Epithelial cells at many sites in the body are affected by the inherited disorder cystic fibrosis (CF). The lung was the major focus of research until recently, when effective therapeutics became available for most people with CF. There is now renewed interest in CF aetiology in other locations in the body, where the regulatory mechanisms for ...
Ayushi Umrigar, Katreya Lovrenert, Jenny L. Kerschner, Neeraj Sharma, Britney Tian, Rebecca Melton, Kyu Shik Mun, Nirbhayaditya Vaghela, Mina Ogawa, Gedge D. Rosson, Shinichiro Ogawa, Anjaparavanda P. Naren, Kyle J. Gaulton, Shih‐Hsing Leir, Ann Harris   +14 more
wiley   +1 more source

FoxO3 Activation Alleviates Doxorubicin‐Induced Cardiomyopathy by Enhancing Autophagic Flux and Suppressing mTOR/ROS Signalling

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Doxorubicin (DOX) is an effective chemotherapy drug, but its use is limited by cardiotoxicity, known as DOX‐induced cardiomyopathy. The transcription factor FoxO3, which regulates autophagy and oxidative stress, has unclear mechanisms in this condition.
Zao‐Shang Chang, Le Wang, Ju‐Xiang Zhou, Mei‐Xiu‐Li Li, Meng‐Yun Yang, Bin Luo, Jia‐Jun Liu, Xiao‐Ye Sun, Jing‐Bo Xia   +8 more
wiley   +1 more source

Deuterium-depleted water inhibits the malignant progression of colorectal cancer cells by modulating oxidative stress. [PDF]

Oncol Rep
Li C, Cheng X, Jiang Y.
europepmc   +1 more source

Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Journal of Diabetes Investigation, Volume 16, Issue 8, Page 1371-1381, August 2025.
This finding reveals the important role of Uhrf1 in the β‐cell dedifferentiation of T2D, providing a potential target for its treatment. ABSTRACT Background Islet β‐cell dedifferentiation is a major pathological mechanism of type 2 diabetes (T2D). Forkhead box o1 (Foxo1) is a master regulator of β‐cell dedifferentiation.
Lanfang Fu, Juyun Zhang, Zhu Lin, Xubiao Meng   +3 more
wiley   +1 more source

Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Neurodegenerative and neuroinflammatory diseases, such as Alzheimer's and multiple sclerosis (MS), are characterized by inflammation, nerve cell damage, and a limited capacity for natural repair, which worsens with aging. While neural stem cells (NSCs) show promise for brain repair, their clinical use is limited by safety and delivery challenges.
Eduardo H. Moretti, Ally L. Y. Lin, Luca Peruzzotti‐Jametti, Stefano Pluchino, Sabah Mozafari   +4 more
wiley   +1 more source

Discovery of a novel alpha isoform of the long-known enzyme LDHA provides new insights into cancer research. [PDF]

FEBS J
Park W, Wei S, Ryu D, Ha KT.
europepmc   +1 more source