Results 251 to 260 of about 94,681 (279)

Age‐Dependent KLK8 Upregulation Contributes to Elevated Susceptibility to Ventilator‐Induced Lung Injury in the Elderly Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Our research firstly indicated that age‐dependent upregulation of tissue kallikrein‐related peptidase 8 (KLK8) induces endothelial senescence through modulating the fibronectin‐FAK‐Akt‐PARP1/2 axis, thereby increasing the vulnerability of aged mice to low‐tidal‐volume ventilator‐induced lung injury (VILI).
Di Liu, Tian‐Tian Lin, Hui Zhang, Ying Zhao, Chu‐Fan Xu, Yu‐Jian Liu, Lai Jiang, Xiao‐Yan Zhu   +7 more
wiley   +1 more source

β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition. [PDF]

World J Diabetes
Al Madhoun A, Bahman F, Ahmad R.
europepmc   +1 more source

The forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis

, 2019
Hannah M. Flood, Craig Bolte, Nupur Dasgupta, Akanksha Sharma, Yufang Zhang, Chandrashekhar R. Gandhi, Tanya V. Kalin, Vladimir V. Kalinichenko   +7 more
openalex   +1 more source

FoxO1 Responses to Chronic Oxidative Stress to Participate in Age‐Related Osteoporosis by Depriving β‐Catenin From TCF7

Aging Cell, Volume 25, Issue 1, January 2026.
Chronic oxidative stress caused by MACF1 deficiency leads to a functional switch in osteoblasts from “osteogenic differentiation” to “antioxidation.” FoxO1 responds to oxidative stress by altering the destination of β‐catenin and disrupting the balance of the FoxO1/β‐catenin–Wnt/β‐catenin pathway, thereby inhibiting osteoblast differentiation ...
Peihong Su, Xiaoli Ma, Chong Yin, Ruilin Shi, Siyu Chen, Lihuizi Yang, Meng Qu, Xinyao Jia, Qi Yu, Hui Li, Airong Qian, Ye Tian   +11 more
wiley   +1 more source

Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways.

Development, 2016
Ahmad SM, Bhattacharyya P, Jeffries N, Gisselbrecht SS, Michelson AM.   +4 more
europepmc   +1 more source

Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells. [PDF]

Helicobacter, 2012
Tabassam FH, Graham DY, Yamaoka Y.
europepmc   +1 more source

Tumor‐Derived Prostaglandin E2 Promotes Colorectal Cancer Progression by Inducing N2‐Type TAN Polarization

Cancer Science, Volume 117, Issue 1, Page 19-32, January 2026.
We demonstrated that PGE2 released from LDs in CRC cells plays important roles in N2‐type TANs polarization. PGE2 enters neutrophils through its receptor EP2/EP4 to stimulate ROS‐mediated FOXO3a methylation, thereby increasing the polarization of N2‐type TANs.
Yue Han, Wen Chen, Bin Zhang, Shuang Wang   +3 more
wiley   +1 more source

Regulatory mechanisms of Th9 cell differentiation. [PDF]

Front Immunol
Liu X, Li Y, Wu W, Huang H, Hao Y, Song C.   +5 more
europepmc   +1 more source

GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4. [PDF]

J Biol Chem, 2014
Huo X, Liu S, Shao T, Hua H, Kong Q, Wang J, Luo T, Jiang Y.   +7 more
europepmc   +1 more source

DNA methylation shapes transcription factor binding beyond canonical CpG contexts. [PDF]

Proc Natl Acad Sci U S A
Miodownik I, Solozabal R, O'Hagan MP, Albeck S, Peleg Y, Takac M, Afek A.   +6 more
europepmc   +1 more source