Results 51 to 60 of about 216,058 (206)

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development. [PDF]

Front Cell Dev Biol, 2021
Ruiz-Losada M, Pérez-Reyes C, Estella C.   +2 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. [PDF]

Nucleic Acids Res, 2021
Li J, Dai S, Chen X, Liang X, Qu L, Jiang L, Guo M, Zhou Z, Wei H, Zhang H, Chen Z, Chen L, Chen Y.   +12 more
europepmc   +1 more source

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations. [PDF]

Nucleic Acids Res, 2021
Dai S, Qu L, Li J, Chen Y.
europepmc   +1 more source

Transcriptional Control of the Forkhead Thyroid Transcription Factor TTF-2 by Thyrotropin, Insulin, and Insulin-like Growth Factor I [PDF]

, 1997
Lourdes Ortíz, Mariastella Zannini, Roberto Di Lauro, Pilar Santisteban   +3 more
openalex   +1 more source

Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia. [PDF]

Mil Med Res, 2021
Han RH, Huang HM, Han H, Chen H, Zeng F, Xie X, Liu DY, Cai Y, Zhang LQ, Liu X, Xia ZY, Tang J.   +11 more
europepmc   +1 more source

Noise-filtering features of transcription regulation in the yeast S. cerevisiae [PDF]

arXiv, 2007
Transcription regulation is largely governed by the profile and the dynamics of transcription factors' binding to DNA. Stochastic effects are intrinsic to this dynamics and the binding to functional sites must be controled with a certain specificity for living organisms to be able to elicit specific cellular responses.
arxiv  

Unified nomenclature for the winged helix/forkhead transcription factors [PDF]

, 2000
Klaus H. Kaestner, Walter Knöchel, Daniel E. Martínez   +2 more
openalex   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source