Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]
, 2019 Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
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FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]
, 2008 Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P. +4 more
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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation [PDF]
Developmental Cell, 2003 An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion.
Nakae, Jun +5 more
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FoxO Proteins in the Nervous System
Analytical Cellular Pathology, 2015 Acute as well as chronic disorders of the nervous system lead to significant morbidity and mortality for millions of individuals globally. Given the ability to govern stem cell proliferation and differentiated cell survival, mammalian forkhead ...
Kenneth Maiese
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FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Current Research in Structural Biology, 2022 Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families.
Emil Spreitzer +8 more
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Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. [PDF]
, 2004 FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear.
Akagi, Tadaatsu +8 more
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Regulation of Ace2-dependent genes requires components of the PBF complex in schizosaccharomyces pombe [PDF]
, 2015 The division cycle of unicellular yeasts is completed with the activation of a cell separation program that results in the dissolution of the septum assembled during cytokinesis between the 2 daughter cells, allowing them to become independent entities ...
Alonso-Nuñez, María Luisa +4 more
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The Forkhead Transcription Factor FOXK2 Promotes AP-1-Mediated Transcriptional Regulation [PDF]
Molecular and Cellular Biology, 2012 The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs.
Ji, Zongling +5 more
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The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors
Cells, 2023 Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore +2 more
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Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex [PDF]
, 2018 ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause.
Alonso-Nunez +54 more
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